A future for CD3 antibodies in immunotherapy of type 1 diabetes
More than 30 years have passed since the first immunotherapy trials in autoimmune insulin-dependent type 1 diabetes were conducted . At this time, it was already apparent, given the compelling observations of the central role of CD4 and CD8 autoreactive T cells in the destruction of insulin-secreting beta-cells, that the immune system of patients would be the most effective drug target, though few tools were available. Small molecule immunosuppressants, such as ciclosporin, were transforming treatment of organ transplant rejection as they proved to be more effective than the conventional therapies, corticosteroids and azathioprine. Based on these observations, ciclosporin was tested in patients with recently diagnosed type 1 diabetes. The results of these first trials provided a fundamental proof-of-concept: that it was possible to effectively treat patients with established hyperglycaemia because, contrary to the prevailing dogma, even after disease diagnosis, a significant mass...
KeywordsAutoimmune diabetes CD3 monoclonal antibodies Immunotherapy T lymphocytes Teplizumab Type 1 diabetes
Autoimmunity-Blocking Antibody for Tolerance
Mixed-meal tolerance test
Programmed cell death 1
The author was the sole contributor to this paper.
Duality of interest
The author has received an honorarium from Provention Bio.
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