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Diabetologia

pp 1–12 | Cite as

Breastfeeding at night is rarely followed by hypoglycaemia in women with type 1 diabetes using carbohydrate counting and flexible insulin therapy

  • Lene Ringholm
  • Ann B. Roskjær
  • Susanne Engberg
  • Henrik U. Andersen
  • Anna L. Secher
  • Peter Damm
  • Elisabeth R. Mathiesen
Article

Abstract

Aims/hypothesis

Hypoglycaemia in association with breastfeeding is a feared condition in mothers with type 1 diabetes. Thus, routine carbohydrate intake at each breastfeed, particularly at night, is often recommended despite lack of evidence. We aimed to evaluate glucose levels during breastfeeding, focusing on whether night-time breastfeeding induced hypoglycaemia in mothers with type 1 diabetes.

Methods

Of 43 consecutive mothers with type 1 diabetes, 33 (77%) were included prospectively 1 month after a singleton delivery. Twenty-six mothers (mean [SD] age 30.7 [5.8] years, mean [SD] duration of diabetes 18.6 [10.3] years) were breastfeeding and seven mothers (mean [SD] age 31.7 [5.6] years, mean [SD] duration of diabetes 20.4 [6.2] years) were bottle-feeding their infants with formula. All were experienced in carbohydrate counting using individually tailored insulin therapy with insulin analogues (45% on insulin pump, 55% on multiple daily injections). Thirty-two women with type 1 diabetes, matched for age ±1 year and BMI ±1 kg/m2, who had not given birth or breastfed in the previous year, served as a control group. Blinded continuous glucose monitoring (CGM) for 6 days was applied at 1, 2 and 6 months postpartum in the breastfeeding mothers who recorded breastfeeds and carbohydrate intake at each CGM period. CGM was applied at 1 month postpartum in the formula-feeding mothers and once in the control women. The insulin dose was individually tailored after each CGM period.

Results

The percentage of night-time spent with CGM <4.0 mmol/l was low (4.6%, 3.1% and 2.7% at each CGM period in the breastfeeding mothers vs 1.6% in the control women, p = 0.77), and the breastfeeding mothers spent a greater proportion of the night-time in the target range of 4.0–10.0 mmol/l (p = 0.01). Symptomatic hypoglycaemia occurred two or three times per week at 1, 2 and 6 months postpartum in both breastfeeding mothers and the control women. Severe hypoglycaemia was reported by one mother (3%) during the 6 month postpartum period and by one control woman (3%) in the previous year (p = 0.74). In breastfeeding mothers at 1 month, the insulin dose was 18% (−67% to +48%) lower than before pregnancy (p = 0.04). In total, carbohydrate was not consumed in relation to 438 recorded night-time breastfeeds, and CGM <4.0 mmol/l within 3 h occurred after 20 (4.6%) of these breastfeeds.

Conclusions/interpretation

The percentage of night-time spent in hypoglycaemia was low in the breastfeeding mothers with type 1 diabetes and was similar in the control women. Breastfeeding at night-time rarely induced hypoglycaemia. The historical recommendation of routine carbohydrate intake at night-time breastfeeding may be obsolete in mothers with type 1 diabetes who have properly reduced insulin dose with sufficient carbohydrate intake.

Trial registration

ClinicalTrials.gov NCT02898428

Keywords

Breastfeeding Carbohydrate counting Continuous glucose monitoring Gestational weight gain retention Hypoglycaemia Insulin dose Insulin pump therapy Type 1 diabetes 

Abbreviations

CGM

Continuous glucose monitoring

IOM

Institute of Medicine

SMPG

Self-monitoring of plasma glucose

Notes

Acknowledgements

We are grateful to the women who participated in this study. We thank registered nurse M. Glindorf and patient coordinator L. Løndam at the Steno Diabetes Center Copenhagen, Denmark, for practical help during the conduction of this study. Some of the data were presented as an abstract at the 78th ADA Annual Meeting in 2018 and at the 54th EASD Annual Meeting in 2018.

Data availability

Data can be obtained by contacting the corresponding author.

Contribution statement

All authors contributed to the conception and design of the study, acquired the data and analysed and interpreted data. LR drafted the article. ABR, SE, ALS, HUA, PD and ERM revised drafts critically for important intellectual content. All authors gave final approval of the version to be published. LR is responsible for the integrity of the work as a whole.

Funding

This research received a grant from the Beckett Foundation. There was no public or commercial funding. Ascensia Diabetes Care Denmark Aps provided the glucometers ContourNext free of charge. The iPro2 Professional CGM devices were purchased at the regular cost negotiated with the Capital Region of Copenhagen.

Duality of interest

HUA owns stocks in Novo Nordisk A/S and participates in advisory boards for AstraZeneca and Novo Nordisk A/S. PD and ERM are participating in multicentre and multinational clinical studies on the use of insulin in pregnant women with pre-existing diabetes in collaboration with Novo Nordisk; no personal honorarium is involved. PD and ERM are in the speaker’s bureau of Novo Nordisk. All other authors declare that there is no duality of interest associated with their contribution to this manuscript.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Lene Ringholm
    • 1
    • 2
    • 3
  • Ann B. Roskjær
    • 2
    • 3
  • Susanne Engberg
    • 1
  • Henrik U. Andersen
    • 1
  • Anna L. Secher
    • 2
    • 3
  • Peter Damm
    • 2
    • 4
    • 5
  • Elisabeth R. Mathiesen
    • 2
    • 3
    • 5
  1. 1.Steno Diabetes Center CopenhagenGentofteDenmark
  2. 2.Center for Pregnant Women with DiabetesRigshospitaletCopenhagenDenmark
  3. 3.Department of EndocrinologyRigshospitaletCopenhagenDenmark
  4. 4.Department of ObstetricsRigshospitaletCopenhagenDenmark
  5. 5.The Institute of Clinical Medicine, Faculty of Health and Medical SciencesUniversity of CopenhagenCopenhagenDenmark

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