Antihypertensive medication prior to nocturnal sleep reduces the risk of new-onset type 2 diabetes in hypertensive patients: a role for slow-wave sleep?
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KeywordsAntihypertensive medication Chronotherapy Sleep Type 2 diabetes
Sympathetic nervous system
To the Editor: I read with great interest the study by Hermida et al . In their study involving 2,012 hypertensive patients without type 2 diabetes, it was found that regular bedtime vs morning intake of antihypertensive medication reduced the risk of new-onset type 2 diabetes, with the strongest risk reduction associated with the use of ACE inhibitors. Moreover, compared with the morning-treatment group, patients on the bedtime medication schedule exhibited a larger relative blood pressure decline across sleep. These findings provide novel evidence as they suggest that circadian timing of antihypertensive medication can alter patients’ type 2 diabetes risk. The question is: why do ACE inhibitors have such a protective effect against diabetes when intake is scheduled prior to nocturnal sleep?
The author’s work is supported by research grants from the Swedish Brain Foundation, AFA Insurance (Sweden), and Novo Nordisk Foundation (Denmark).
Duality of interest
The author is unaware of any affiliation, funding or financial holdings that might be perceived as affecting the objectivity of this commentary. The author declares that there is no duality of interest associated with this manuscript.
The author was the sole contributor to this paper.