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Der Urologe

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Modifizierbare und nichtmodifizierbare Risikofaktoren für Urolithiasis

  • F. PrausEmail author
  • M. Schönthaler
Leitthema

Zusammenfassung

Die Kenntnis der Risikofaktoren für eine Urolithiasis bildet die Basis für eine suffiziente Metaphylaxe und Reduktion von Rezidivereignissen. Zu den modifizierbaren Risikofaktoren gehören neben der Ernährung und Trinkmenge auch Beruf, Umweltfaktoren, die Anzahl der Schwangerschaften sowie das intestinale Mikrobiom. Assoziierte Erkrankungen, durch deren Behandlung das Erkrankungs- und Rezidivrisiko für Urolithiasis gesenkt werden kann, betreffen insbesondere die verschiedenen Ausprägungen des metabolischen Syndroms. Die Kenntnis nichtmodifizierbarer Risikofaktoren wie Geschlecht, Ethnie, positive Familienanamnese sowie spezifische genetische Defekte und Polymorphismen des Calcium- und Phosphathaushalts ermöglichen eine personalisierte Beratung und Nachsorge der betreffenden Patienten.

Schlüsselwörter

Metaphylaxe Rezidiv Prävention Oxalobacter formigenes Sozioökonomischer Status 

Abkürzungen

AOR

„Adjusted odds ratio“ (korrigierte Odds Ratio)

CAC

„Coronary artery calcification“ (Verkalkung der Koronarien)

EPIC-Oxford

Britische Subkohorte der European Prospective Investigation into Cancer and Nutrition

HR

Hazard Ratio

MET

„Metabolic equivalent of task“ (metabolisches Äquivalent)

NHANES

National Health and Nutrition Examination Survey

NHS

„Nurses’ health study“

OR

Odds Ratio

Oxf

Oxalobacter formigenes

RR

Relatives Risiko

SCCS

„Southern community cohort study“

SES

„Socioeconomic status“ (sozioökonomischer Status)

Modifiable and non-modifiable risk factors for urolithiasis

Abstract

Knowledge of the risk factors for urolithiasis is the key for sufficient metaphylaxis and reduction of recurrence events. Modifiable risk factors include diet, drink quantity, occupation, environmental factors, number of pregnancies and the intestinal microbiome. The treatment of associated diseases, such as the various manifestations of metabolic syndrome can reduce the risk for urolithiasis and recurrences. Knowledge of non-modifiable risk factors, such as gender, ethnicity, positive family history as well as specific genetic defects and polymorphisms of the calcium and phosphate balance enables personalized counselling and follow-up of affected patients.

Keywords

Metaphylaxis Recurrence Prevention Oxalobacter formigenes Socioeconomic status 

Notes

Einhaltung ethischer Richtlinien

Interessenkonflikt

F. Praus und M. Schönthaler geben an, dass kein Interessenkonflikt besteht.

Für diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.

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Copyright information

© Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2019

Authors and Affiliations

  1. 1.Klinik für UrologieUniversitätsklinikum FreiburgFreiburgDeutschland

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