Journal of Molecular Medicine

, Volume 97, Issue 10, pp 1377–1383 | Cite as

The dichotomous function of interleukin-9 in cancer diseases

  • K. Gerlach
  • B. WeigmannEmail author


The pleiotropic function of the cytokine IL-9 is so far described in many inflammation processes and autoimmune diseases. But its role in cancer immunology is rather diverse as it can have a pro-tumorigenic function as well as anti-tumorigenic characteristics. In various disease models of cancer, this cytokine is involved in different signaling pathways triggering the expression of proteins involved in cell growth, migration, and transformation or repressing cells from the adaptive immune system to reject tumor growth. Additionally, there are even therapeutic approaches for IL-9 in cancer development. This review will give an overview of the various roles of IL-9 in different immune organs and cells and provide an insight in the current state of research in the IL-9-dependent cancer area.


IL-9 Pro-tumorigenic role Anti-tumorigenic role Therapy 



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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Medicine 1, Kussmaul Campus for Medical ResearchUniversity of Erlangen-NurembergErlangenGermany
  2. 2.Medical Immunology Campus Erlangen, Medical Clinic 1Friedrich-Alexander University Erlangen-NürnbergErlangenGermany

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