Skip to main content
Log in

Perioperative Betreuung von Patienten mit diastolischer Herzinsuffizienz

Schnittstelle zur Anästhesie

Perioperative care of patients with diastolic heart failure

Interface to anesthesia

  • Allgemeinanästhesie
  • Published:
Der Anaesthesist Aims and scope Submit manuscript

Zusammenfassung

Das Vorliegen einer diastolischen Herzinsuffizienz geht mit einer erhöhten perioperativen Morbidität und Mortalität einher. Die Prävalenz dieser Erkrankung ist zunehmend, und mehrere Risikofaktoren konnten bereits identifiziert werden. Hierzu zählen neben höherem Patientenalter und weiblichem Geschlecht insbesondere arterielle Hypertonie, Diabetes mellitus und koronare Herzerkrankung (KHK). Außer der klinischen Untersuchung und Laborbestimmungen steht v. a. die Echokardiographie im Zentrum der Diagnosestellung und perioperativen Evaluierung. Im transmitralen Flussprofil kann über das Verhältnis des frühen passiven Bluteinstroms (E) zu dem durch die Vorhofkontraktion ausgelösten späten, aktiven Einstrom (A) der Schweregrad der diastolischen Dysfunktion festgelegt werden. Daten bezüglich des idealen Narkoseverfahrens fehlen großteils, der Einsatz einer thorakalen Epiduralanästhesie scheint aber vorteilhaft zu sein. Intraoperativ ist bei Patienten mit diastolischer Herzinsuffizienz besonders auf den Volumenstatus zu achten, da sich sowohl Hypo- als auch Hypervolämie negativ auswirken. Zusätzlich gefährden Arrhythmien und Blutdruckschwankungen diese Patientengruppe in besonderem Maß.

Abstract

Diastolic heart failure leads to an increase in perioperative morbidity and mortality. The prevalence of this disease is rising and multiple risk factors have already been identified. Besides higher age and female gender, arterial hypertension, diabetes mellitus and coronary artery disease in particular have to be considered. Clinical examination and laboratory analyses are important for preoperative evaluation; however, echocardiography plays the most important role in the diagnostics of diastolic heart failure. The transmitral flow profile can be used to differentiate the grades of diastolic dysfunction using the ratio between early passive ventricular filling (E) and late active filling due to atrial contraction (A). Data concerning the ideal anesthesia technique are for the most part lacking; however, the application of thoracic epidural anesthesia seems to be beneficial. A great deal of attention has to be paid to the intraoperative volume status of patients with diastolic dysfunction as hypovolemia and hypervolemia can both have detrimental effects. Arrhythmias and major changes in blood pressure put this special group of patients at additional risks.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abb. 1
Abb. 2
Abb. 3
Abb. 4
Abb. 5
Abb. 6

Literatur

  1. Paulus WJ, Tschöpe C, Sanderson JE et al (2007) How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology. Eur Heart J 28:2539–2550

    Article  PubMed  Google Scholar 

  2. European Study Group on Diastolic Heart Failure (1998) How to diagnose diastolic heart failure. Eur Heart J 19:990–1003

    Article  Google Scholar 

  3. Owan TE, Hodge DO, Herges RM et al (2006) Trends in prevalence and outcome of heart failure with preserved ejection fraction. N Engl J Med 355:251–259

    Article  CAS  PubMed  Google Scholar 

  4. Hogg K, Swedberg K, McMurray J (2004) Heart failure with preserved left ventricular systolic function; epidemiology, clinical characteristics and prognosis. J Am Coll Cardiol 43:317–327

    Article  PubMed  Google Scholar 

  5. Redfield MM, Jacobsen SJ, Burnett JC et al (2003) Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic. JAMA 289:194–202

    Article  PubMed  Google Scholar 

  6. McMurray JJ, Pfeffer MA (2005) Heart failure. Lancet 365:1877–1889

    Article  PubMed  Google Scholar 

  7. Cleland JG, Tendera M, Adamus J et al (2006) The perindopril in elderly people with chronic heart failure (PEP-CHF) study. Eur Heart J 27:2338–2345

    Article  CAS  PubMed  Google Scholar 

  8. Kuznetsova T, Herbots L, López B et al (2009) Prevalence of left ventricular diastolic dysfunction in a general population. Circ Heart Fail 2:105–112

    Article  PubMed  Google Scholar 

  9. Angeja BG, Grossman W (2003) Evaluation and management of diastolic heart failure. Circulation 107:659–663

    Article  PubMed  Google Scholar 

  10. Liu JE, Palmieri V, Roman MJ et al (2001) The impact of diabetes on left ventricular filling pattern in normotensive and hypertensive adults: the strong heart study. J Am Coll Cardiol 37:1943–1949

    Article  CAS  PubMed  Google Scholar 

  11. Vishwanath V, Frank KE, Elmets CA et al (1986) Glycation of skin collagen in type I diabetes mellitus. Correlation with long-term complications. Diabetes 35:916–921

    Article  CAS  PubMed  Google Scholar 

  12. Van Hoeven KH, Factor SM (1990) A comparison of the pathological spectrum of hypertensive, diabetic, and hypertensive-diabetic heart disease. Circulation 82:848–855

    Article  Google Scholar 

  13. Zile MR, Baicu CF, Gaasch WH (2004) Diastolic heart failure – abnormalities in active relaxation and passive stiffness of the left ventricle. N Engl J Med 350:1953–1959

    Article  CAS  PubMed  Google Scholar 

  14. McMurray JJ, Adamopoulos S, Anker SD et al (2012) ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur Heart J 33:1787–1847

    Article  PubMed  Google Scholar 

  15. Nagueh SF, Appleton CP, Gillebert TC et al (2009) Recommendations for the evaluation of left ventricular diastolic function by echocardiography. Eur J Echocardiogr 10:165–193

    Article  PubMed  Google Scholar 

  16. Erbel R, Neumann T, Zeidan Z et al (2002) Echocardiography diagnosis of diastolic heart failure. Herz 27:99–106

    Article  PubMed  Google Scholar 

  17. Oki T, Tabata T, Yamada H et al (1997) Clinical application of pulsed Doppler tissue imaging for assessing abnormal left ventricular relaxation. Am J Cardiol 79:921–928

    Article  CAS  PubMed  Google Scholar 

  18. Van Kraaij DJ, van Pol PE, Ruiters AW et al (2002) Diagnosing diastolic heart failure. Eur J Heart Fail 4:419–430

    Article  Google Scholar 

  19. Mair J, Hammerer-Lercher A, Puschendorf B (2001) The impact of cardiac natriuretic peptide determination on the diagnosis and management of heart failure. Clin Chem Lab Med 39:571–588

    Article  CAS  PubMed  Google Scholar 

  20. Maisel AS, McCord J, Nowak RM et al (2003) Bedside B-type natriuretic peptide in the emergency diagnosis of heart failure with reduced or preserved ejection fraction. J Am Coll Cardiol 41:2010–2017

    Article  PubMed  Google Scholar 

  21. Edelmann F, Gelbrich G, Düngen H-D et al (2011) Exercise training improves exercise capacity and diastolic function in patients with heart failure with preserved ejection fraction: results of the Ex-DHF (Exercise training in Diastolic Heart Failure) pilot study. J Am Coll Cardiol 58:1780–1791

    Article  PubMed  Google Scholar 

  22. Poldermans D, Bax JJ, Boersma E et al (2009) Guidelines for preoperative cardiac risk assessment and perioperative cardiac management in non-cardiac surgery. Eur Heart J 30:2769–2812

    Article  PubMed  Google Scholar 

  23. Clark JA, Subramaniam B (2012) Diastolic heart failure: perioperative management. Int Anesthesiol Clin 50:171–186

    Article  PubMed  Google Scholar 

  24. Flu W, van Kuijk J-P, Hoeks SE et al (2010) Prognostic implications of asymptomatic left ventricular dysfunction in patients undergoing vascular surgery. Anesthesiology 112:1316–1324

    Article  PubMed  Google Scholar 

  25. Landesberg G, Gilon D, Meroz Y et al (2012) Diastolic dysfunction and mortality in severe sepsis and septic shock. Eur Heart J 33:895–903

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  26. Papanikolaou J, Makris D, Saranteas T et al (2011) New insights into weaning from mechanical ventilation: left ventricular diastolic dysfunction is a key player. Intensive Care Med 37:1976–1985

    Article  Google Scholar 

  27. Meierhenrich R, Schütz W, Gauss A (2008) Left ventricular diastolic dysfunction. Implications for anesthesia and critical care. Anaesthesist 57:1053–1068

    Article  CAS  PubMed  Google Scholar 

  28. Bolliger D, Seeberger MD, Kasper J et al (2010) Different effects of sevoflurane, desflurane, and isoflurane on early and late left ventricular diastolic function in young healthy adults. Br J Anaesth 104:547–554

    Article  CAS  PubMed  Google Scholar 

  29. Pirracchio R, Cholley B, De Hert S et al (2007) Diastolic heart failure in anaesthesia and critical care. Br J Anaesth 98:707–721

    Article  CAS  PubMed  Google Scholar 

  30. Sarkar S, GuhaBiswas R, Rupert E (2010) Echocardiographic evaluation and comparison of the effects of isoflurane, sevoflurane and desflurane on left ventricular relaxation indices in patients with diastolic dysfunction. Ann Card Anaesth 13:130–137

    Article  PubMed  Google Scholar 

  31. Filipovic M, Michaux I, Wang J et al (2007) Effects of sevoflurane and propofol on left ventricular diastolic function in patients with pre-existing diastolic dysfunction. Br J Anaesth 98:12–18

    Article  CAS  PubMed  Google Scholar 

  32. Pagel PS, Schmeling WT, Kampine JP, Warltier DC (1992) Alteration of canine left ventricular diastolic function by intravenous anesthetics in vivo. Ketamine and propofol. Anesthesiology 76:419–425

    Article  CAS  PubMed  Google Scholar 

  33. Pagel PS, Grossman W, Haering JM, Warltier DC (1993) Left ventricular diastolic function in the normal and diseased heart. Perspectives for the anesthesiologist (2). Anesthesiology 79:1104–1120

    Article  CAS  PubMed  Google Scholar 

  34. Schmidt C, Hinder F, Van Aken H et al (2005) The effect of high thoracic epidural anesthesia on systolic and diastolic left ventricular function in patients with coronary artery disease. Anesth Analg 100:1561–1569

    Article  CAS  PubMed  Google Scholar 

  35. Rodgers A, Walker N, Schug S et al (2000) Reduction of postoperative mortality and morbidity with epidural or spinal anaesthesia: results from overview of randomised trials. BMJ 321:1–12

    Article  Google Scholar 

  36. Rigg JR, Jamrozik K, Myles PS et al (2002) Epidural anaesthesia and analgesia and outcome of major surgery: a randomised trial. Lancet 359:1276–1282

    Article  PubMed  Google Scholar 

  37. Gandhi SK, Powers JC, Nomeir AM et al (2001) The pathogenesis of acute pulmonary edema associated with hypertension. N Engl J Med 344:17–22

    Article  CAS  PubMed  Google Scholar 

  38. Zile MR, Brutsaert DL (2002) New concepts in diastolic dysfunction and diastolic heart failure: Part II: causal mechanisms and treatment. Circulation 105:1503–1508

    Article  PubMed  Google Scholar 

  39. Parissis JT, Panou F, Farmakis D et al (2005) Effects of levosimendan on markers of left ventricular diastolic function and neurohormonal activation in patients with advanced heart failure. Am J Cardiol 96:423–426

    Article  CAS  PubMed  Google Scholar 

  40. Jörgensen K, Bech-Hanssen O, Houltz E et al (2008) Effects of levosimendan on left ventricular relaxation and early filling at maintained preload and afterload conditions after aortic valve replacement for aortic stenosis. Circulation 117:1075–1081

    Article  PubMed  Google Scholar 

  41. Connelly KA, Royse C, Royse AG (2011) Tissue Doppler Em and instantaneous end-diastolic stiffness: validation against pressure-volume loops in patients undergoing coronary artery bypass surgery. Heart Lung Circ 20:223–230

    Article  PubMed  Google Scholar 

Download references

Einhaltung ethischer Richtlinien

Interessenkonflikt. S. Heschl, C. Colantonio, B. Pieske und W. Toller geben an, dass kein Interessenkonflikt besteht. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to S. Heschl.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Heschl, S., Colantonio, C., Pieske, B. et al. Perioperative Betreuung von Patienten mit diastolischer Herzinsuffizienz. Anaesthesist 63, 951–957 (2014). https://doi.org/10.1007/s00101-014-2404-x

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00101-014-2404-x

Schlüsselwörter

Keywords

Navigation