Comment to Impact of postmastectomy radiotherapy on the outcomes of breast cancer patients with T1-2 N1 disease; an individual patient data analysis of three clinical trials
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Abdel-Rahman  analyzed the overall survival-rate and disease-free survival of T1-2 N1 breast cancer patients after mastectomy, who were adjuvantly treated with various modern chemotherapeutic drugs (anthracyclines, taxanes) in 3 prospective phase III chemotherapy trials. His analysis suggested no potential benefits of an additional adjuvant postmastectomy radiotherapy (PMRT). The included trials were the BIG 02/98 , the BCIRG 001  and the BCIRG-005  trials. The author concludes that in T1-2 N1 breast cancer patients who have received modern chemotherapy drugs PMRT does not provide any benefit for overall and disease-free survival. Prospective studies are necessary.
PMRT has shown a survival benefit in many randomized trials and meta-analyses, in addition to a reduction in locoregional recurrence rate (LRR) in locally advanced breast cancer. The Early Breast Cancer Trialist’ Collaborative Group (EBCTCG) demonstrated that PMRT resulted in a reduction in LRR after...
Conflict of interest
C. Matuschek, D. Krug, R.J. Klement and R. Baumann declare that they have no competing interests.
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