Strahlentherapie und Onkologie

, Volume 195, Issue 4, pp 306–307 | Cite as

Comment to Impact of postmastectomy radiotherapy on the outcomes of breast cancer patients with T1-2 N1 disease; an individual patient data analysis of three clinical trials

  • Christiane MatuschekEmail author
  • David Krug
  • Rainer J. Klement
  • René Baumann
Letter to the Editor

Abdel-Rahman [1] analyzed the overall survival-rate and disease-free survival of T1-2 N1 breast cancer patients after mastectomy, who were adjuvantly treated with various modern chemotherapeutic drugs (anthracyclines, taxanes) in 3 prospective phase III chemotherapy trials. His analysis suggested no potential benefits of an additional adjuvant postmastectomy radiotherapy (PMRT). The included trials were the BIG 02/98 [6], the BCIRG 001 [7] and the BCIRG-005 [5] trials. The author concludes that in T1-2 N1 breast cancer patients who have received modern chemotherapy drugs PMRT does not provide any benefit for overall and disease-free survival. Prospective studies are necessary.


PMRT has shown a survival benefit in many randomized trials and meta-analyses, in addition to a reduction in locoregional recurrence rate (LRR) in locally advanced breast cancer. The Early Breast Cancer Trialist’ Collaborative Group (EBCTCG) demonstrated that PMRT resulted in a reduction in LRR after...


Conflict of interest

C. Matuschek, D. Krug, R.J. Klement and R. Baumann declare that they have no competing interests.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Christiane Matuschek
    • 1
    Email author
  • David Krug
    • 2
    • 3
    • 6
  • Rainer J. Klement
    • 4
  • René Baumann
    • 5
    • 6
  1. 1.Klinik für Strahlentherapie und RadioonkologieMedical Faculty, Universitätsklinikum Düsseldorf, Heinrich-Heine UniversitätDüsseldorfGermany
  2. 2.RadioOnkologie und StrahlentherapieUniversitätsKlinikum HeidelbergHeidelbergGermany
  3. 3.National Center for Radiation Research in Oncology (NCRO)Heidelberg Institute for Radiation Oncology (HIRO)HeidelbergGermany
  4. 4.Klinik für Strahlentherapie und RadioonkologieLeopoldina Krankenhaus SchweinfurtSchweinfurtGermany
  5. 5.Klinik für RadioOnkologie und StrahlentherapieSt. Marienkrankenhaus SiegenSiegenGermany
  6. 6.Klinik für StrahlentherapieUniversitätsklinikum Schleswig-HolsteinKielGermany

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