Strahlentherapie und Onkologie

, Volume 188, Issue 11, pp 975–981 | Cite as

Anti-inflammatory effects of low-dose radiotherapy

Indications, dose, and radiobiological mechanisms involved
  • M. ArenasEmail author
  • S. Sabater
  • V. Hernández
  • A. Rovirosa
  • P.C. Lara
  • A. Biete
  • J. Panés
Review article


Low-dose radiotherapy (LD-RT) has been used for several benign diseases, including arthrodegenerative and inflammatory pathologies. Despite its effectiveness in clinical practice, little is known about the mechanisms through which LD-RT modulates the various phases of the inflammatory response and about the optimal dose fractionation. The objective of this review is to deepen knowledge about the most effective LD-RT treatment schedule and radiobiological mechanisms underlying the anti-inflammatory effects of LD-RT in various in vitro experiments, in vivo studies, and clinical studies.


Low-dose radiotherapy Leukocyte Endothelium Adhesion molecules Benign diseases 

Entzündungshemmende Effekte von niedrigdosierter Strahlentherapie

Indikationen, Dosis und zugrundeliegende radiobiologische Mechanismen


Niedrigdosierte Strahlentherapie (LD-RT) wird für die Behandlung verschiedener gutartiger Erkrankungen, einschließlich für arthrodegenerative und entzündliche Erkrankungen verwendet. Obwohl diese in der Praxis effektiv sind, wissen wir noch sehr wenig über die zugrundeliegenden Mechanismen der entzündungshemmenden Wirkung und die optimale Dosisfraktionierung. Das Ziel des Artikels ist es, unser Wissen über LD-RT und die zugrundeliegenden entzündungshemmenden Effekte in verschiedenen In-vitro-Versuchen und In-vivo-Studien sowie in klinischen Studien zu vertiefen.


Niedrigdosierte Strahlentherapie Leukozyten Endothelium Adhäsionsmoleküle Gutartige Erkrankungen 


Conflict of interest

On behalf of all authors, the corresponding author states that there are no conflicts of interest.


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Copyright information

© Urban & Vogel 2012

Authors and Affiliations

  • M. Arenas
    • 1
    Email author
  • S. Sabater
    • 2
  • V. Hernández
    • 3
  • A. Rovirosa
    • 4
  • P.C. Lara
    • 5
  • A. Biete
    • 6
  • J. Panés
    • 7
  1. 1.Radiation Oncology Department. Hospital Universitari Sant Joan de Reus, Institut d’Investigacions Sanitàries Pere Virgili (IISPV)Universitat Rovira i Virgili (URV)ReusSpain
  2. 2.Radiation Oncology DepartmentComplejo Hospitalario Universitario de AlbaceteAlbaceteSpain
  3. 3.Physics DepartmentHospital Universitari Sant Joan de Reus, IISPVTarragonaSpain
  4. 4.Radiation Oncology DepartmentHospital Clínic de Barcelona, Institut de Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona (UB)BarcelonaSpain
  5. 5.Radiation Oncology DepartmentHospital Universitario Dr Negrín, Las Palmas de Gran Canaria, Universidad Las Palmas de Gran Canaria (LPGC)CanariaSpain
  6. 6.Radiation Oncology DepartmentHospital Clínic de Barcelona, Institut de Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona (UB)BarcelonaSpain
  7. 7.Gastroenterology DepartmentHospital Clínic de Barcelona, Institut de Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona (UB)BarcelonaSpain

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