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Effect of new oral anticoagulants on platelet indices in non-valvular atrial fibrillation patients

  • Irfan Veysel DuzenEmail author
  • Elif Oguz
  • Yusuf Cekici
  • Fethi Yavuz
  • Ertan Vuruskan
  • Isa Sincer
  • Fatih Poyraz
  • Hayri Alıcı
  • Umit Yuksek
  • Abdullah Orhan Demirtas
  • Murat Sucu
Original articles


New-generation oral anticoagulants (NOACs) are now preferred as a first-line treatment in the management of atrial fibrillation for prevention of thromboembolic complications. Mean platelet volume (MPV), one of the indicators of increased platelet activity, is also associated with an increased stroke risk in atrial fibrillation patients. The aim of this study was to evaluate changes in MPV, platelet distribution width (PDW) and plateletcrit following use of NOACs. The study included 116 patients with non-valvular atrial fibrillation without previous NOAC use. Complete blood counts, biochemical analyses and echocardiography were performed for all patients. No significant differences were observed in MPV or other platelet indices at 6 months compared to baseline. Our results indicate that MPV and other platelet indices are not affected by NOAC use in non-valvular atrial fibrillation patients.


Arrhythmias Stroke Risk factors Echocardiography INR 

Wirkung neuer oraler Antikoagulanzien auf Thrombozytenparameter bei Patienten mit nichtvalvulärem Vorhofflimmern


Neue orale Antikoagulanzien (NOAC) werden mittlerweile für die Erstlinientherapie bei Vorhofflimmern zur Prävention thromboembolischer Komplikationen bevorzugt eingesetzt. Das mittlere Thrombozytenvolumen („mean platelet volume“ [MPV]), ein Indikator der erhöhten Thrombozytenaktivität, ist auch mit einem erhöhten Schlaganfallrisiko bei Patienten mit Vorhofflimmern assoziiert. Ziel der vorliegenden Studie war es, Veränderungen im MPV, der Thrombozytenverteilungsbreite und dem Thrombokrit nach Einsatz von NOAC zu untersuchen. Eingeschlossen wurden 116 Patienten mit nichtvalvulärem Vorhofflimmern ohne vorherige NOAC-Einnahme. Bei allen Patienten wurden große Blutbilder erstellt, zudem wurden biochemische Analysen und eine Echokardiographie durchgeführt. Im Vergleich zur Ausgangsmessung fanden sich nach 6 Monaten keine signifikanten Unterschiede im MPV oder in anderen Thrombozytenparametern. Unsere Ergebnisse zeigen, dass das MPV und andere Thrombozytenparameter bei Patienten mit nichtvalvulärem Vorhofflimmern nicht durch eine NOAC-Einnahme beeinträchtigt sind.


Herzrhythmusstörungen Schlaganfall Risikofaktoren Echokardiographie INR 


Compliance with ethical guidelines

Conflict of interest

I.V. Duzen, E. Oguz, Y. Cekici, F. Yavuz, E. Vuruskan, I. Sincer, F. Poyraz, H. Alıcı, U. Yuksek, A.O. Demirtas and M. Sucu declare that they have no competing interests.

All procedures performed in studies involving human participants or on human tissue were in accordance with the ethical standards of the institutional and/or national research committee and with the 1975 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2019

Authors and Affiliations

  • Irfan Veysel Duzen
    • 1
    Email author
  • Elif Oguz
    • 2
  • Yusuf Cekici
    • 3
  • Fethi Yavuz
    • 4
  • Ertan Vuruskan
    • 1
  • Isa Sincer
    • 5
  • Fatih Poyraz
    • 6
  • Hayri Alıcı
    • 7
  • Umit Yuksek
    • 8
  • Abdullah Orhan Demirtas
    • 4
  • Murat Sucu
    • 1
  1. 1.Faculty of Medicine, Department of CardiologyGaziantep UniversityGaziantepTurkey
  2. 2.Faculty of Medicine, Department of PharmacologyMedeniyet UniversityIstanbulTurkey
  3. 3.Department of CardiologySanlıurfa Mehmet Akif Inan Research and Training HospitalSanlıurfaTurkey
  4. 4.Department of CardiologyAdana City Education and Research HospitalAdanaTurkey
  5. 5.Faculty of Medicine, Department of CardiologyAbant Izzet Baysal UniversityBoluTurkey
  6. 6.Department of CardiologyGaziantep Defa Life HospitalGaziantepTurkey
  7. 7.Department of CardiologyGaziantep Hatem HospitalGaziantepTurkey
  8. 8.Faculty of Medicine, Department of CardiologyYakın Dogu UniversityNicosiaCyprus

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