, Volume 44, Issue 4, pp 347–353 | Cite as

Plasma osteopontin levels in patients with dilated and hypertrophic cardiomyopathy

  • J. Podzimkova
  • T. PalecekEmail author
  • P. Kuchynka
  • J. Marek
  • B. A. Danek
  • M. Jachymova
  • M. Kalousova
  • T. Zima
  • A. Linhart
Original articles



Osteopontin (OPN) is an extracellular matrix glycoprotein that plays a role in a variety of cellular activities associated with inflammatory and fibrotic responses. Increased OPN levels in myocardium and plasma have been demonstrated in patients with dilated cardiomyopathy (DCM). However, nothing is known about OPN levels in patients with hypertrophic cardiomyopathy (HCM). Therefore, the aim of our study was to compare plasma OPN levels in patients with these two most common cardiomyopathies.

Patients and methods

We examined plasma OPN as well as creatinine, C‑reactive protein (CRP), brain-type natriuretic peptide (BNP), and troponin I levels in 64 patients with DCM, 43 patients with HCM, and 75 control subjects. Transthoracic echocardiography was also performed on all cardiomyopathy patients.


Plasma OPN levels were significantly elevated in patients with DCM compared with HCM patients (95 ± 43 vs. 57 ± 21 ng/ml; p < 0.001) and control subjects (54 ± 19 ng/ml; p < 0.001); however, there was no difference between HCM patients and control subjects. New York Heart Association (NYHA) class III or IV disease was more frequently present in DCM patients than in HCM subjects (44 % vs. 2 %, p < 0.0001). In multivariate analysis, BNP and CRP levels together with NYHA class were found to be significant predictors of plasma OPN levels in DCM patients (p = 0.002, p = 0.029, and p < 0.001 for BNP, CRP, and NYHA, respectively).


Plasma OPN levels were associated with overall heart failure severity rather than with specific cardiomyopathy subtype in patients suffering from DCM or HCM, respectively.


Extracellular matrix glycoprotein Cardiomyopathies Heart failure Myocardium Ventricular remodeling 

Osteopontinspiegel im Plasma bei dilatativer und hypertrophischer Kardiomyopathie



Osteopontin (OPN) ist ein Glykoprotein der extrazellulären Matrix, das bei verschiedenen zellulären Prozessen im Rahmen entzündlicher und fibrotischer Reaktionen eine Rolle spielt. Erhöhte OPN-Spiegel im Myokard und im Plasma wurden bei Patienten mit dilatativer Kardiomyopathie (DCM) nachgewiesen. Es ist jedoch nichts über die OPN-Spiegel bei Patienten mit hypertrophischer Kardiomyopathie (HCM) bekannt. Daher war es Ziel der vorliegenden Studie, die OPN-Spiegel bei Patienten mit diesen beiden häufigsten Kardiomyopathien zu vergleichen.

Patienten und Methoden

Es wurden die Werte für OPN im Plasma sowie Kreatinin, C‑reaktives Protein (CRP), BNP („brain-type natriuretic peptide“) und Troponin I bei 64 Patienten mit DCM, 43 Patienten mit HCM und 75 Kontrollen ermittelt. Auch wurde bei allen Kardiomyopathiepatienten eine transthorakale Echokardiographie durchgeführt.


Die OPN-Werte im Plasma waren bei Patienten mit DCM im Vergleich zu HCM-Patienten (95 ± 43 vs. 57 ± 21 ng/ml; p < 0,001) und Kontrollen (54 ± 19 ng/ml; p < 0,001) signifikant erhöht; jedoch bestand kein Unterschied zwischen HCM-Patienten und Kontrollen. Eine Erkrankung der Klasse III oder IV gemäß New York Heart Association (NYHA) lag häufiger bei Patienten mit DCM als bei Patienten mit HCM vor (44 % vs. 2 %, p < 0,0001). In der multivariaten Analyse erwiesen sich die BNP- und CRP-Werte zusammen mit der NYHA-Klasse als signifikante Prädiktoren der OPN-Werte im Plasma bei DCM-Patienten (p = 0,002 für BNP; p = 0,029 für CRP bzw. p < 0,001 für NYHA).


Die OPN-Spiegel im Plasma waren bei Patienten mit DCM oder HCM eher mit dem Gesamtschweregrad der Herzinsuffizienz als mit spezifischen Subtypen der Kardiomyopathie assoziiert.


Glykoprotein der extrazellulären Matrix Kardiomyopathien Herzinsuffizienz Myokard Ventrikuläres Remodeling 



The authors are thankful to Ms. Hana Řeháková of the Institute of Medical Biochemistry and Laboratory Diagnostics for technical assistance.


The study was supported by MH CZ DRO 64165 and Progres Q38/LF1 projects.

Compliance with ethical guidelines

Conflict of interest

J. Podzimkova, T. Palecek, P. Kuchynka, J. Marek, B.A. Danek, M. Jachymova, M. Kalousova, T. Zima, and A. Linhart declare that they have no competing interests.

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975 (in its most recently amended version). Informed consent was obtained from all patients included in the study.


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Copyright information

© Springer Medizin Verlag GmbH 2017

Authors and Affiliations

  • J. Podzimkova
    • 1
  • T. Palecek
    • 1
    Email author
  • P. Kuchynka
    • 1
  • J. Marek
    • 1
  • B. A. Danek
    • 1
  • M. Jachymova
    • 2
  • M. Kalousova
    • 2
  • T. Zima
    • 2
  • A. Linhart
    • 1
  1. 1.2nd Department of Medicine – Department of Cardiovascular Medicine, First Faculty of MedicineCharles University and General University Hospital in PraguePragueCzech Republic
  2. 2.Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of MedicineCharles University and General University Hospital in PraguePragueCzech Republic

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