Familial Takayasu arteritis in a mother and daughter: a report of two cases

Familiäre Takayasu-Arteriitis bei Mutter und Tocher: Bericht über 2 Fälle


Takayasu arteritis (TA) is a chronic granulomatous panarteritis, predominantly affecting the aorta and its main branches. Infections, genetic factors as suggested by familial clustering, and autoimmunity may play a role in its pathogenesis. In this report, we describe familial TA in a mother and daughter with diverse clinical manifestations. In addition to being a familial form of vasculitis, both of our cases demonstrated amyloidosis, chronic renal disease thought to be due to ischemic nephropathy, and hypertensive nephrosclerosis.


Bei der Takayasu-Arteriitis (TA) handelt es sich um eine chronische granulomatöse Panarteriitis, die in erster Linie die Aorta und ihre Hauptäste betrifft. Infektionen, genetische Faktoren, wie Hinweise durch familiäres Clustering ergaben, und Autoimmunität können eine Rolle in der Pathogenese spielen. Hier wird eine familiäre TA bei Mutter und Tochter mit verschiedenen klinischen Manifestationen beschrieben. Neben einer familiären Form der Vaskulitis wiesen beide Fälle eine Amyloidose, eine chronische Niereninsuffizienz – vermutlich infolge ischämischer Nephropathie – und eine hypertensive Nephrosklerose auf.

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On behalf of all authors, the corresponding author states that there are no conflicts of interest.

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Correspondence to A. Deniz.

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Video of renal angiography demonstrating severe in-stent restenosis in left renal artery ( 0,5 MB)

Video of renal angiography demonstrating severe in-stent restenosis in left renal artery ( 0,5 MB)

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Deniz, A., Yildiz, F., Aktas, H. et al. Familial Takayasu arteritis in a mother and daughter: a report of two cases. Herz 38, 93–96 (2013).

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  • Amyloidosis
  • Chronic renal disease
  • Familial Takayasu arteritis
  • Hypertension


  • Amyloidose
  • Chronische Niereninsuffizienz
  • Familiäre Takayasu-Arteriitis
  • Hypertonie