Design, synthesis, and anticancer evaluation of 1,2,4-oxadiazole functionalized quinoline derivatives

  • Pruthu Kala
  • Syed Khasim Sharif
  • CH. Murali Krishna
  • Dittakavi RamachandranEmail author
Original Research


A library of 1,2,4-oxadiazole functionalized quinoline derivatives (13a–j) were synthesized and their structures were confirmed by 1H NMR, 13CNMR and Mass Spectral analysis. Further, these compounds were evaluated for their anticancer activity against four human cancer cell lines, namely MCF-7 (breast), A549 (lung), DU-145 (prostate) and MDA MB-231 (breast) using Etoposide as the positive control. Most of these derivatives exhibited more potent activity towards the four cancer cell lines compared to Etoposide. Amongst all the compounds tested, compounds 13b, 13c, 13h, 13i and 13j exhibited promising activity. Further of these compounds 13b, 13i and 13j exhibited excellent activity, when compared with Etoposide.


Lenvatinib Proxazole Quinoline 1,2,4-oxadiazole Anticancer activity 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Pruthu Kala
    • 1
  • Syed Khasim Sharif
    • 1
  • CH. Murali Krishna
    • 2
  • Dittakavi Ramachandran
    • 1
    Email author
  1. 1.Department of ChemistryAcharya Nagarjuna UniversityNagarjuna NagarIndia
  2. 2.Department of ChemistryAdikavi Nannaya UniversityRajamahendravaramIndia

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