Green synthesis, molecular docking, anti-oxidant and anti-inflammatory activities of α-aminophosphonates
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The naturally viable α-amino acid surrogates have been synthesised via Kabachnik–Fields reaction by the condensation of 2-aminothiazole with various aldehydes and dialkyl phosphites in the presence of Caffeine hydrogen sulfate (CHS) as eco-friendly and reusable catalyst under microwave irradiation and solvent-free conditions. The title compounds were characterised by IR, 1H, 13C, 31P NMR and mass spectral data. All the synthesised (4a–j) compounds were screened for their insilico and in vitro studies. The results revealed that, out of all the titled compounds 4a, 4e, 4h and 4i have exhibited significant activity in terms of antioxidant and anti-inflammatory activity. In addition, molecular docking studies were also carried out against Cox-2 with celocoxib as the standard.
Keywordsα-aminophosphonates Caffeine hydrogen sulfate Antioxidant Anti-inflammatory activity Molecular docking studies
The authors are express grateful thanks to Prof. C. Devendranath Reddy, Department of Chemistry, S.V. University, Tirupati, for his helpful discussions and acknowledge to DST-PURSE 2nd Phase Programme in S.V. University, Tirupati funded by DST-New Delhi, India for providing instrumentation facility and funding to one of the authors Mr Mohan Gundluru through SRF (File No: 17118-UGC-III(3)/DST-PURSE 2nd Phase/2017, Dt: 23-08-2018).
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Conflict of interest
The authors declare that they have no conflict of interest.
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