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Medicinal Chemistry Research

, Volume 28, Issue 8, pp 1099–1131 | Cite as

Sulfa drug analogs: new classes of N-sulfonyl aminated azines and their biological and preclinical importance in medicinal chemistry (2000–2018)

  • Galal H. ElgemeieEmail author
  • Rasha A. Azzam
  • Rasha E. Elsayed
Review Article
  • 27 Downloads

Abstract

N-sulfonylamino azinones has attracted the interest of numerous researchers and extensive investigations on their biological activities have been done. The present review provides an overview of the patents and reports filed during the last few years pertaining to the synthesis N-sulfonyl azinones as well as their biological and preclinical studies. A brief discussion on the significant biological findings is also provided. It has been established that N-sulfonylamino azinones is privileged heterocycles possessing diuretic, antihypertensive, anti-inflammatory, and anticancer and other biological activities. In particular, a new generation of competitive AMPA receptor antagonist based on N-sulfonylamino 1H-quinazoline-2,4-diones is promising useful in the treatment neurological disorders such as epilepsy and schizophrenia. The scope of these new advances has been also highlighted in this review.

Keywords

Sulfa drug analogs N-sulfonyl aminated azines Medicinal chemistry N-sulfonyl aminated pyridines N-sulfonyl aminated pyrimidines 

Notes

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Galal H. Elgemeie
    • 1
    Email author
  • Rasha A. Azzam
    • 1
  • Rasha E. Elsayed
    • 1
  1. 1.Chemistry Department, Faculty of ScienceHelwan UniversityCairoEgypt

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