Medicinal Chemistry Research

, Volume 28, Issue 1, pp 62–70 | Cite as

Synthesis and antimicrobial evaluation of novel N-substituted 4-ethylsulfanyl-2-pyridones and triazolopyridines

  • Rasha A. Azzam
  • Galal H. ElgemeieEmail author
Original Research


The design and development of new methods for the synthesis of antimicrobial drugs is an important goal currently for medicinal chemistry. Sixteen novel N-substituted-amino-, N-arylsulfonylamino-, and N-aryl-4-ethylsulfanyl-2-pyridones were synthesized. Antimicrobial activities of the compounds were evaluated against four fungal and eight bacterial strains. Antimicrobial results showed that compound 14b had excellent activities as compared to all other newly synthesized compounds and a variety of standard ones against a variety of bacterial and fungal strains. Triazolo[1,5-a]pyridines 10c and 10e showed as well marked activities toward three of the tested Gram-negative bacteria.


2-Pyridones N-cyanoacetohydrazide Cyanoaceto-N-phenylsulfonylhydrazide Antimicrobial activity 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Chemistry Department, Faculty of ScienceHelwan UniversityHelwanEgypt

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