Prenyl-flavonoids from Epimedium koreanum Nakai and their soluble epoxide hydrolase and tyrosinase inhibitory activities
- 226 Downloads
A new 8-prenyl-flavonoid, epimedokoreanoside III, and 11 other flavonoids, were isolated from the aerial parts of Epimedium koreanum Nakai. Their chemical structures were elucidated by nuclear magnetic resonance and mass analyzes. All isolates were evaluated for their soluble epoxide hydrolase and tyrosinase inhibitory activities. Among the isolates, compounds 1, 5, 9, 10, and 12 exerted soluble epoxide hydrolase inhibitory activity in dose-dependent manner, with IC50 values ranging from 26.0 ± 1.2 to 37.6 ± 1.0 µM, whereas compounds 4 and 9 showed potent inhibition of tyrosinase in a dose-dependent manner, having IC50 values of 16.8 ± 2.7 and 8.7 ± 2.7 µM, respectively.
KeywordsEpimedium koreanum Nakai Berberidaceae Flavonoids Soluble epoxide hydrolase Tyrosinase
This work was supported by research fund of Chuangnam National University, and also supported by a grant (K17281) awarded to the Korean Institute of Oriental Medicine by the Ministry of Education, Science and Technology (MEST).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no competing interests.
- Cho WK, Kim H, Choi YJ, Yim NH, Yang HJ, Ma JY (2012) Epimedium Koreanum Nakai water extract exhibits antiviral activity against porcine epidermic diarrhea virus in vitro and in vivo. Evid Based Complement Alternat Med 2012:1–10Google Scholar
- Kim ES, Kim MK, Kang HK, Park YI, Dong MS, Kim DH, Chung HS (2008) Flavonol glycosides with antioxidant activity from the aerial parts of Epimedium koreanum Nakai. Nat Prod Sci 14:233–238Google Scholar
- Pyo MK, Koo YK, Yun-Choi HS (2002) Anti-platelet effect of the phenolic constituents isolated from the leaves of Magnolia obovata. J Nat Prod 8:147–151Google Scholar
- Sun PW, Wen Y, Xu Y, Pei YP, Chen YJ, Noriko S, Tadahiro T (1998) The chemical constituents of Epimedium koreanum Nakai. Acta Pharmacol Sin 33:919–922Google Scholar
- Won DH, Gu HA, Kim HJ, Han SB, Park J, Park SN (2013) Antibacterial and antioxidative activities of Epimedium koreanum Nakai extracts. J Microbiol Biotechnol 41:284–291Google Scholar