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Medicinal Chemistry Research

, Volume 26, Issue 11, pp 2761–2767 | Cite as

Prenyl-flavonoids from Epimedium koreanum Nakai and their soluble epoxide hydrolase and tyrosinase inhibitory activities

  • Xiang Dong Su
  • Wei Li
  • Ji Eun Kim
  • Seo Young Yang
  • Jin Yeul Ma
  • Young Ho Kim
Original Research
  • 216 Downloads

Abstract

A new 8-prenyl-flavonoid, epimedokoreanoside III, and 11 other flavonoids, were isolated from the aerial parts of Epimedium koreanum Nakai. Their chemical structures were elucidated by nuclear magnetic resonance and mass analyzes. All isolates were evaluated for their soluble epoxide hydrolase and tyrosinase inhibitory activities. Among the isolates, compounds 1, 5, 9, 10, and 12 exerted soluble epoxide hydrolase inhibitory activity in dose-dependent manner, with IC50 values ranging from 26.0 ± 1.2 to 37.6 ± 1.0 µM, whereas compounds 4 and 9 showed potent inhibition of tyrosinase in a dose-dependent manner, having IC50 values of 16.8 ± 2.7 and 8.7 ± 2.7 µM, respectively.

Keywords

Epimedium koreanum Nakai Berberidaceae Flavonoids Soluble epoxide hydrolase Tyrosinase 

Notes

Acknowledgements

This work was supported by research fund of Chuangnam National University, and also supported by a grant (K17281) awarded to the Korean Institute of Oriental Medicine by the Ministry of Education, Science and Technology (MEST).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

Supplementary material

44_2017_1975_MOESM1_ESM.doc (1.7 mb)
Supplementary Information

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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  1. 1.College of PharmacyChungnam National UniversityDaejeonRepublic of Korea
  2. 2.Korean Medicine (KM) Application Center, Korea Institute of Oriental MedicineDaeguRepublic of Korea

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