Farnesoid X receptor alpha (FXRα) is a critical actor of the development and pathologies of the male reproductive system

  • Manon Garcia
  • Laura Thirouard
  • Mélusine Monrose
  • Hélène Holota
  • Angélique De Haze
  • Françoise Caira
  • Claude BeaudoinEmail author
  • David H. VolleEmail author


The farnesoid-X-receptorα (FXRα; NR1H4) is one of the main bile acid (BA) receptors. During the last decades, through the use of pharmalogical approaches and transgenic mouse models, it has been demonstrated that the nuclear receptor FXRα controls numerous physiological functions such as glucose or energy metabolisms. It is also involved in the etiology or the development of several pathologies. Here, we will review the unexpected roles of FXRα on the male reproductive tract. FXRα has been demonstrated to play functions in the regulation of testicular and prostate homeostasis. Even though additional studies are needed to confirm these findings in humans, the reviewed reports open new field of research to better define the effects of bile acid-FXRα signaling pathways on fertility disorders and cancers.


Bile acid signaling Fertility Cancer 



The study was funded by Inserm, CNRS, Université Clermont Auvergne, Région Auvergne (#R12087CC to DHV), Plan cancer (C14012CS), Ligue contre le cancer (comité Puy de Dôme), ARC (R16142CC). Volle’s team received support from the French government IDEX-ISITE initiative 16-IDEX-0001 (CAP 20-25).

Compliance with ethical standards

Conflict of interest

The authors declare to have no conflict of interests.


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Manon Garcia
    • 1
  • Laura Thirouard
    • 1
  • Mélusine Monrose
    • 1
  • Hélène Holota
    • 1
  • Angélique De Haze
    • 1
  • Françoise Caira
    • 1
  • Claude Beaudoin
    • 1
    Email author
  • David H. Volle
    • 1
    Email author
  1. 1.Inserm U1103, Université Clermont Auvergne, CNRS UMR-6293, GReDClermont-FerrandFrance

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