Cellular and Molecular Life Sciences

, Volume 76, Issue 24, pp 4813–4828 | Cite as

Epigenetic control of embryo–uterine crosstalk at peri-implantation

  • Shuangbo Kong
  • Chan Zhou
  • Haili Bao
  • Zhangli Ni
  • Mengying Liu
  • Bo He
  • Lin Huang
  • Yang Sun
  • Haibin WangEmail author
  • Jinhua LuEmail author


Embryo implantation is one of the pivotal steps during mammalian pregnancy, since the quality of embryo implantation determines the outcome of ongoing pregnancy and fetal development. A large number of factors, including transcription factors, signalling transduction components, and lipids, have been shown to be indispensable for embryo implantation. Increasing evidence also suggests the important roles of epigenetic factors in this critical event. This review focuses on recent findings about the involvement of epigenetic regulators during embryo implantation.


Implantation Epigenetic regulation Uterine receptivity Blastocyst activation decidualization 



This review article was supported in parts by National Key R&D program of China (2017YFC1001402 to H.W.), and the National Natural Science Foundation (81601285 to S.K., 81830045 and 81490744 to H. W. and 31600945 to J.L.) and Fundamental Research Funds for the Central Universities (20720180039 to S.K., 20720180041 to J.L.).


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Shuangbo Kong
    • 1
    • 2
  • Chan Zhou
    • 2
  • Haili Bao
    • 2
  • Zhangli Ni
    • 2
  • Mengying Liu
    • 2
  • Bo He
    • 2
  • Lin Huang
    • 1
    • 2
  • Yang Sun
    • 1
    • 2
  • Haibin Wang
    • 1
    • 2
    Email author
  • Jinhua Lu
    • 1
    • 2
    Email author
  1. 1.Reproductive Medical CenterThe First Affiliated Hospital of Xiamen UniversityXiamenPeople’s Republic of China
  2. 2.Fujian Provincial Key Laboratory of Reproductive Health Research, School of MedicineXiamen UniversityXiamenPeople’s Republic of China

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