Cellular and Molecular Life Sciences

, Volume 76, Issue 22, pp 4503–4510 | Cite as

Cell-surface molecule-mediated cell–cell interactions in the regulation of ILC2-driven allergic inflammation

  • Aihua Lei
  • Jie ZhouEmail author


Group 2 innate lymphoid cells (ILC2s) are a subset of innate immune cells that do not express antigen receptors. ILC2-mediated type 2 responses, which are mainly characterized by the production of interleukin (IL)-5 and IL-13, play key roles in inducing inflammation, protecting against infection, and maintaining tissue homeostasis. Although recent years have largely enhanced our understanding of the transcriptional networks and soluble mediators that regulate ILC2 development or function, emerging evidence suggests that ILC2s express a variety of cell-surface molecules and interact with themselves or other immune cells. These cell–cell interactions are essential in the modulation of ILC2 number and their type 2 cytokine production during ILC2-driven allergic inflammation. In this review, we summarize the extensive array of cell-surface molecules on ILC2s that mediate cell–cell interactions and their role in regulating ILC2 generation or function in the context of ILC2-induced allergic inflammation.


ILC2 Cell-surface molecules Allergic inflammation 



This work was supported by the following grants to J. Zhou: National Natural Science Foundation of China (Nos. 91542112; 81571520; 81771665; 81742002), Start-up Fund for High-level Talents of Tianjin Medical University, Science and Technology Program of Guangzhou (No. 201707010452), Natural Science Foundation of Guangdong Province (No. 2017B030311014). It was also supported by National Natural Science Foundation of China (No. 81800031 to A. Lei), Natural Science Foundation of Guangdong Province (No. 2018A030313648 to A. Lei) and Research Foundation of Education Bureau of Human Province, China (No. 18C0458).

Compliance with ethical standards

Conflict of interest

The authors have no financial conflict of interest.


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Authors and Affiliations

  1. 1.Institute of Pathogenic Biology, Hengyang Medical CollegeUniversity of South ChinaHengyangChina
  2. 2.Hunan Provincial Key Laboratory for Special Pathogens Prevention and ControlUniversity of South ChinaHengyangChina
  3. 3.Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Immunology, School of Basic Medical SciencesTianjin Medical UniversityTianjinChina

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