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Cellular and Molecular Life Sciences

, Volume 76, Issue 4, pp 745–755 | Cite as

How toll-like receptors reveal monocyte plasticity: the cutting edge of antiinflammatory therapy

  • Catherine RopertEmail author
Review
  • 150 Downloads

Abstract

Toll-like receptors (TLR)s are central in immune response by recognizing pathogen-associated molecular patterns (PAMP)s. If they are essential to eliminate pathogens in earlier stages of infection, they also might play a role in homeostasis and tissue repair. TLR versatility parallels the plasticity of monocytes, which represent an heterogeneous population of immune cells. They are rapidly recruited to sites of infection and involved in clearance of pathogens and in tissue healing. This review underlines how TLRs have proved to be an interesting tool to study the properties of monocytes and why different therapeutic strategies exploring monocyte plasticity may be relevant in the context of chronic inflammatory disorders.

Keywords

Monocytes TLR Mal/TIRAP IRAK4 Inflammation 

Notes

Compliance with ethical standards

Conflict of interest

The author declares that there is no conflict of interest.

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© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.Departamento de Bioquímica e Imunologia, Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

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