Cellular and Molecular Life Sciences

, Volume 76, Issue 4, pp 653–665 | Cite as

TGF-β signaling pathway mediated by deubiquitinating enzymes

  • Soo-Yeon Kim
  • Kwang-Hyun BaekEmail author


Ubiquitination is a reversible cellular process mediated by ubiquitin-conjugating enzymes, whereas deubiquitinating enzymes (DUBs) detach the covalently conjugated ubiquitin from target substrates to counter ubiquitination. DUBs play a crucial role in regulating various signal transduction pathways and biological processes including apoptosis, cell proliferation, DNA damage repair, metastasis, differentiation, etc. Since the transforming growth factor-β (TGF-β) signaling pathway participates in various cellular functions such as inflammation, metastasis and embryogenesis, aberrant regulation of TGF-β signaling induces abnormal cellular functions resulting in numerous diseases. This review focuses on DUBs regulating the TGF-β signaling pathway. We discuss the molecular mechanisms of DUBs involved in TGF-β signaling pathway, and biological and therapeutic implications for various diseases.


Deubiquitination Post-translational modification Proteasomal degradation TGF-β Ubiquitination 



We would like to thank members of Baek’s laboratory for their critical comments on the manuscript. This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (201600490003).

Author contributions

SYK: manuscript writing; KHB: manuscript writing, final approval of manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.Department of Biomedical ScienceCHA UniversitySeongnamRepublic of Korea

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