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The functional role of sodium taurocholate cotransporting polypeptide NTCP in the life cycle of hepatitis B, C and D viruses

  • Carla Eller
  • Laura Heydmann
  • Che C. Colpitts
  • Eloi R. Verrier
  • Catherine Schuster
  • Thomas F. Baumert
Review

Abstract

Chronic hepatitis B, C and D virus (HBV, HCV and HDV) infections are a major cause of liver disease and cancer worldwide. Despite employing distinct replication strategies, the three viruses are exclusively hepatotropic, and therefore depend on hepatocyte-specific host factors. The sodium taurocholate co-transporting polypeptide (NTCP), a transmembrane protein highly expressed in human hepatocytes that mediates the transport of bile acids, plays a key role in HBV and HDV entry into hepatocytes. Recently, NTCP has been shown to modulate HCV infection of hepatocytes by regulating innate antiviral immune responses in the liver. Here, we review the current knowledge of the functional role and the molecular and cellular biology of NTCP in the life cycle of the three major hepatotropic viruses, highlight the impact of NTCP as an antiviral target and discuss future avenues of research.

Keywords

Liver cell biology Bile acid transport Host factor Anti-viral therapy Hepatocytes 

Notes

Acknowledgements

This work was supported by Inserm, the University of Strasbourg, the European Union (ERC-2014-AdG-671231-HEPCIR, Infect-ERA hepBccc, EU H2020 Hep-CAR 667273), ANRS (2015/1099), the French Cancer Agency (ARC IHU201301187) and the National Institute of Allergy and Infectious Diseases of the National Institutes of Health under award number R03AI131066. CCC acknowledges fellowships from the Canadian Institutes of Health Research (201411MFE-338606-245517) and the Canadian Network on Hepatitis C. ERV is the recipient of an ANRS fellowship (ECTZ50121).

Author contributions

CFE, LH, CCC, ERV, CS, TFB wrote the manuscript.

Compliance with ethical standards

Conflict of interest

The authors have no conflicting interests to disclose.

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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.Inserm, U1110Institut de Recherche sur les Maladies Virales et HépatiquesStrasbourgFrance
  2. 2.Université de StrasbourgStrasbourgFrance
  3. 3.Division of Infection and ImmunityUniversity College LondonLondonUK
  4. 4.Institut Hospitalo-Universitaire, Pôle Hépato-digestifNouvel Hôpital CivilStrasbourgFrance

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