Inflammation Research

, Volume 68, Issue 5, pp 347–349 | Cite as

Association of − 757T > C polymorphism of C-reactive protein gene with chronic periodontitis of South Indian population

  • Sreekanth M. Selvaraj
  • Judith J. Christina
  • Sinthuja Gurumoorthy
  • Bagavad Gita Jayaraman
  • Adaikkalam VellaichamyEmail author
Short Communication



CRP gene polymorphism is common in inflammatory diseases, but such association has not been reported in periodontitis. Our objective was to interrogate SNPs of crp in chronic periodontitis in a case–control manner.


DNAs were extracted from mouthwash samples of 116 volunteers using salting-out method. Selected 12 5′UTR SNPs of crp were genotyped using ARMS–PCR.


TC genotype of − 757T > C polymorphism (rs3093059) showed protective association (OR— 0.29, 95%CI—0.12–0.68, and p—0.004), and wild type − 757TT showed susceptible association with a p value of 0.008 (OR—3.09, 95%CI—1.33–7.15).


The observation of protective and susceptible association of crp − 757T > C polymorphism may be useful for better management and prophylaxis of periodontitis.


C-reactive protein (CRP) Chronic periodontitis (CP) Amplification refractory mutation system (ARMS)–PCR Single-nucleotide polymorphism (SNP) 



The authors acknowledge support from DBT-BUILDER programme (Ref.: BT/PR12153/INF/22/200/2014), Government of India.

Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest.

Ethical approval

Ethical clearance for the study was obtained from the Institutional Ethical Committee of Sree Balaji Dental College and Hospital, Pallikaranai, Chennai, India—600100 (Ethics Committee Registration No: ECR/761/Inst/TN/2015).

Informed consent

Informed consent was obtained from all individual participants.

Supplementary material

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Supplementary material 1 (XLSX 12 KB)
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Supplementary material 2 (DOCX 1186 KB)


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Centre for BiotechnologyAnna UniversityChennaiIndia
  2. 2.Department of Periodontology and Oral ImplantologySree Balaji Dental College and HospitalChennaiIndia

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