Terephthalic acid determination in mineral water stored in PET bottles using a novel magnetic dispersive micro solid-phase extraction followed by high-performance liquid chromatography

  • Samin HamidiEmail author
  • Mahboob Nemati


Contamination in food from packing material can occur in trace quantities. However, the migration of substances from food packing material needs to be evaluated to ensure that the levels are not toxic. Terephthalic acid (TA) can migrate into mineral water stored in polyethylene terephthalate (PET) bottles and pose a wide range of health hazards depending on the toxicological threshold. A magnetic dispersive micro solid-phase extraction (MDMSPE) associated with HPLC–UV was implemented to determine TA levels in mineral water from PET bottles. The calibration curve was constructed with the correlation coefficient up to 0.99 over the concentration range of 50–500 ng/mL. The recoveries ranged from 98 to 105% and the relative standard deviation (RSD) and accuracy was < 8%. This method is quick, sensitive, simple and accurate, and could be applied to determine TA in water stored in PET bottles in a short analysis time.


Food packing material PET bottles Terephthalic acid Migration Solid phase microextraction Mineral water 



This work is part of a project supported by a Grant (58671) from the Food and Drug Safety Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Compliance with ethical standards

Conflict of interest

The authors declare that there is no conflict of interest.

Supplementary material

3_2019_1214_MOESM1_ESM.pdf (104 kb)
Supplementary material 1 (PDF 103 kb)


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Copyright information

© Bundesamt für Verbraucherschutz und Lebensmittelsicherheit (BVL) 2019

Authors and Affiliations

  1. 1.Food and Drug Safety Research Centre, Tabriz University of Medical ScienceTabrizIran
  2. 2.Department of Drug and Food ControlTabriz University of Medical SciencesTabrizIran

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