Advertisement

The Journal of Physiological Sciences

, Volume 65, Supplement 2, pp S17–S22 | Cite as

Gamma wave oscillation and synchronized neural signaling between the lateral hypothalamus and the hippocampus in response to hunger

  • Nifareeda Samerphob
  • Dania Cheaha
  • Surapong Chatpun
  • Ekkasit KumarnsitEmail author
Original Paper
  • 5 Downloads

Abstract

The lateral hypothalamus plays an important role in homeostasis. It is sensitive to negative energy balance and believed to interact with other brain regions to mediate food seeking behavior. However, no neural signaling of hunger in the lateral hypothalamus has been studied. Male Swiss albino mice implanted with intracranial electrodes into the lateral hypothalamus and the hippocampus were randomly treated with drinking water for control condition, 18–20 h deprivation of food for hunger condition, and fluid food for satiety condition. Therefore, local field potential (LFP) and locomotor activity of animals were simultaneously recorded. One way ANOVA with Tukey’s post hoc test was used for statistical analysis. Frequency analysis of LFP revealed that food deprivation significantly increased the power of gamma oscillation (65–95 Hz) in the lateral hypothalamus and the hippocampus. However, satiety did not change the oscillation in these regions. Moreover, no significant difference among groups was observed for locomotor count and speed. The analysis of coherence values between neural signaling of these two brain areas also confirmed significant increase within a frequency range of 61–92 Hz for hunger. No change in coherence value was induced by satiety. In summary, this study demonstrated neural signaling of the lateral hypothalamus in response to hunger with differential power spectrum of LFP and the interplay with the hippocampus. The data may suggest critical roles of the lateral hypothalamus in detection of negative energy balance and coordination of other higher functions for food related learning or behaviors through the connectivity with the hippocampus.

Keywords

Lateral hypothalamus Hippocampus Local field potential Hunger Energy balance 

References

  1. 1.
    Berthoud HR, H Münzberg (2011) The lateral hypothalamus as integrator of metabolic and environmental needs: From electrical self-stimulation to opto-genetics. Physiol & behavior 104(1): 29–39.CrossRefGoogle Scholar
  2. 2.
    Anand BK, JR Brobeck (1951) Hypothalamic Control of Food Intake in Rats and Cats. The Yale Journal of Biology and Medicine 24(2): 123–140.PubMedPubMedCentralGoogle Scholar
  3. 3.
    Delgado JMR, BK Anand (1952) Increase of food intake induced by electrical stimulation of the lateral hypothalamus. American Journal of Physiology—Legacy Content 172(1): 162–168.CrossRefGoogle Scholar
  4. 4.
    Johnstone LE, TM Fong, G Leng (2006) Neuronal activation in the hypothalamus and brainstem during feeding in rats. Cell metabolism 4(4): 313–321.CrossRefGoogle Scholar
  5. 5.
    Li D, Olszewski P, Shi Q, Grace M, Billington CJ, Kotz CM, Levine AS (2006) Effect of opioid receptor ligands injected into the rostral lateral hypothalamus on c-fos and feeding behavior. Brain Research 1096(1): 120–124.CrossRefGoogle Scholar
  6. 6.
    Hettes SR, Gonzaga WJ, Heyming TW, Nguyen JK, Perez S, Stanley BG (2010) Stimulation of lateral hypothalamic AMPA receptors may induce feeding in rats. Brain Research 1346: 112–120.CrossRefGoogle Scholar
  7. 7.
    Maldonado-Irizarry C, Swanson C, Kelley A (1995) Glutamate receptors in the nucleus accumbens shell control feeding behavior via the lateral hypothalamus. The Journal of Neuroscience 15(10): 6779–6788.CrossRefGoogle Scholar
  8. 8.
    Castro DC, Cole S, Berridge K (2015) Lateral hypothalamus, nucleus accumbens, and ventral pallidum roles in eating and hunger: interactions between homeostatic and reward circuitry. Frontiers in Systems Neuroscience 9(90): 1–17.Google Scholar
  9. 9.
    Siegel A, Tassoni JP (1971) Differential Efferent Projections from the Ventral and Dorsal Hippocampus of the Cat. Brain, Behavior and Evolution 4(3): 185–200.CrossRefGoogle Scholar
  10. 10.
    Wilson CL, Motter BC, Lindsley DB (1976) Influences of hypothalamic stimulation upon septal and hippocampal electrical activity in the cat. Brain Research 107(1): 55–68.CrossRefGoogle Scholar
  11. 11.
    Leach L, Whishaw IQ, Kolb B (1980) Effects of kainic acid lesions in the lateral hypothalamus on behavior and hippocampal and neocortical electroencephalographic (EEG) activity in the rat. Behavioural Brain Research 1(5): 411–431.CrossRefGoogle Scholar
  12. 12.
    Anchel H, Lindsley DB (1972) Differentiation of two reticulohypothalamic systems regulating hippocampal activity. Electroencephalography and Clinical Neurophysiology 32(3): 209–226.CrossRefGoogle Scholar
  13. 13.
    Cheaha D, Bumrungsri S, Chatpun S, Kumarnsit E (2015) Characterization of in utero valproic acid mouse model of autism by local field potential in the hippocampus and the olfactory bulb. Neuroscience Research 98: 28–34.CrossRefGoogle Scholar
  14. 14.
    Paxinos G, Franklin K (2001) The mouse brain atlas in stereotaxic coordinates. San Diego.Google Scholar
  15. 15.
    Anand BK, Brobeck JR (1951) Hypothalamic control of food intake in rats and cats. The Yale Journal of Biology and Medicine 24(2): 123.PubMedPubMedCentralGoogle Scholar
  16. 16.
    Bernardis LL, Bellinger LL (1993) The lateral hypothalamic area revisited: Neuroanatomy, body weight regulation, neuroendocrinology and metabolism. Neuroscience & Biobehavioral Reviews 17(2): 141–193.CrossRefGoogle Scholar
  17. 17.
    Cho Kathleen KA, Hoch R, Lee AT, Patel T, Rubenstein JLR, Sohal VS (2015) Gamma Rhythms Link Prefrontal Interneuron Dysfunction with Cognitive Inflexibility in Dlx5/6+/− Mice. Neuron 85(6): 1332–1343.CrossRefGoogle Scholar
  18. 18.
    Pietersen AN, Lancaster DM, Patel N, Hamilton JB, Vreugdenhil M (2009) Modulation of gamma oscillations by endogenous adenosine through A1 and A2A receptors in the mouse hippocampus. Neuropharmacology 56(2): 481–492.CrossRefGoogle Scholar
  19. 19.
    Buzsaki G, Geisler C, Henze DA, Wang XJ (2004) Interneuron Diversity series: Circuit complexity and axon wiring economy of cortical interneurons. Trends in Neurosciences 27(4): 186–193.CrossRefGoogle Scholar
  20. 20.
    Traub RD, Spruston N, Soltesz I, Konnerth A, Whittington MA, Jefferys JGR (1998) Gamma-frequency oscillations: a neuronal population phenomenon, regulated by synaptic and intrinsic cellular processes, and inducing synaptic plasticity. Progress in neurobiology 55(6): 563–575.CrossRefGoogle Scholar
  21. 21.
    Llinás R, Moreno H (1998) Local Ca2+ signaling in neurons. Cell Calcium 24(5-6): 359–366.CrossRefGoogle Scholar

Copyright information

© The Physiological Society of Japan and Springer Japan 2015

Authors and Affiliations

  • Nifareeda Samerphob
    • 1
  • Dania Cheaha
    • 2
  • Surapong Chatpun
    • 3
  • Ekkasit Kumarnsit
    • 1
    Email author
  1. 1.Department of Physiology, Faculty of SciencePrince of Songkla UniversityHat Yai, SongkhlaThailand
  2. 2.Faculty of MedicinePrincess of Naradhiwas University (PNU)Meang, NarathiwatThailand
  3. 3.Institute of Biomedical Engineering, Faculty of MedicinePrince of Songkla UniversityHat Yai, SongkhlaThailand

Personalised recommendations