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Canadian Journal of Public Health

, Volume 99, Issue 2, pp 102–106 | Cite as

Neonatal Vitamin A Deficiency and Its Impact on Acute Respiratory Infections among Preschool Inuit Children

  • Cynthia Cameron
  • Frédéric Dallaire
  • Carole Vézina
  • Gina Muckle
  • Suzanne Bruneau
  • Pierre Ayotte
  • Eric DewaillyEmail author
Article

Abstract

Objective

To assess if vitamin A concentration in umbilical cord blood is associated with incidence and severity of respiratory infections in preschool Inuit children from Nunavik (Québec, Canada).

Method

The medical charts of 305 children were reviewed from 0 to 5 years of age. The association between vitamin A concentration in umbilical cord plasma and the incidence rates of acute otitis media (AOM), lower respiratory tract infections (LRTIs) and hospitalization rates for LRTIs was evaluated using Poisson regression.

Results

Compared to children with vitamin A concentration >-20 μg/dl, adjusted rate ratios (RR) for children below 20 μg/dl ranged between 1.06–1.62 for AOM, 1.12–1.34 for LRTIs, and 1.09–1.43 for hospitalization for LRTIs. Most RRs were statistically significant for AOM and LRTIs, but not for hospitalization for LRTIs.

Conclusion

Neonatal vitamin A deficiency appears to be a significant risk factor for AOM and LRTIs in this population.

Key words

Vitamin A deficiency Inuits nutritional status respiratory tract infections otitis media infant child risk factor 

Résumé

Objectif

Évaluer si la concentration de vitamine A dans le sang de cordon ombilical est associée avec l’incidence et la sévérité des infections respiratoires chez les enfants inuits d’âge préscolaire au Nunavik (Québec, Canada).

Méthode

Les dossiers médicaux couvrant les 5 premières années de vie de 305 enfants ont été examinés. L’association entre la concentration de vitamine A dans le sang de cordon ombilical et ‘incidence d’otite moyenne aiguë (OMA), d’infections des voies respiratoires inférieures (IVRI) et d’hospitalisations pour des IVRI a été évaluée à l’aide du modèle de régression de Poisson.

Résultats

Comparativement aux enfants ayant des concentrations de vitamine A >-20 μg/dL, les taux d’incidences relatifs ajustés (TR) des enfants avec des concentrations <20 μg/dL étaient compris entre 1,06 et 1,62 pour les OMA, entre 1,1 2 et 1,34 pour les IVRI et entre 1,09 et 1,43 pour les hospitalisations pour IVRI. La plupart des TR étaient statistiquement significatifs pour les OMA et les IVRI, mais pas pour les hospitalisations.

Conclusion

Une déficience néonatale en vitamine A semble être un facteur de risque significatif d’OMA et d’IVRI dans cette population.

Mots clés

déficience en vitamine A Inuit statut nutritionnel infection des voies respiratoires otite moyenne aiguë nourrisson enfant facteur de risque 

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Copyright information

© The Canadian Public Health Association 2008

Authors and Affiliations

  • Cynthia Cameron
    • 1
  • Frédéric Dallaire
    • 2
  • Carole Vézina
    • 1
  • Gina Muckle
    • 1
  • Suzanne Bruneau
    • 1
  • Pierre Ayotte
    • 1
    • 2
  • Eric Dewailly
    • 1
    • 2
    Email author
  1. 1.Unité de recherche en santé publique, CHUL-CHUQQuebec CityCanada
  2. 2.Department of Social and Preventive Medicine, Faculty of MedicineLaval UniversityCanada

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