Increased Frequency of the S-allele of the L-myc Oncogene in Breast Cancer
Association between restriction fragment length polymorphisms (RFLP) of known oncogenes and a predisposition to develop cancer have been postulated. The L-myc gene is a potential molecular marker associated with cancer susceptibility as well as metastasis, prognosis, and adverse survival. Our aim was to test the hypothesis that there was an association between L-myc S allele in breast cancer and a predisposition to the disease.
Materials and Methods
The distribution of L-myc polymorphism in 56 patients with breast cancer was determined by polymerase chain reaction-based restriction fragment length polymorphism and compared with that of 51 healthy control subjects.
The allele frequencies of L and S in breast cancer patients were 0.70 and 0.30, respectively and those in normal individuals were 0.54 and 0.46, respectively. This difference was primarily the result of a high frequency of the S allele among breast cancer patients compared to controls. The frequency of S allele was significantly higher in breast cancer patients than in normal individuals (p < 0.01). No correlation was observed between the presence of L-myc S allele and several parameters of each patient’s history or characteristics of tumor.
Our results suggested that L-myc polymorphism may be significant in an individual’s susceptibility to breast cancer in Turkey and may be useful for identifying patients at high risk of developing breast cancer.
This study was supported by a grant from the University of Istanbul, Research Foundation (project 1561/16012001).