, Volume 15, Issue 1, pp 99–105 | Cite as

The relationship between retinol-binding protein 4 and apolipoprotein B-containing lipoproteins is attenuated in patients with very high serum triglycerides: A pilot study

  • Georgios A. Christou
  • Constantinos C. Tellis
  • Moses S. Elisaf
  • Alexandras D. Tselepis
  • Dimitrios N. KiortsisEmail author
Research paper


OBJECTIVE: The investigation of the association between retinol-binding protein 4 (RBP4) and lipoproteins in subjects with hypertriglyceridemia. DESIGN: Forty-six obese or overweight hypertriglyceridemic patients were studied at baseline and 20 of them underwent a hypocaloric low-fat diet for 3 months. RESULTS: Plasma RBP4 levels were positively correlated with serum triglycerides (TG) in the subgroup of patients with TG <200 mg/dL (r=0.453, p=0.039) and negatively correlated with TG in patients with TG ≥200 mg/dL (r=−0.487, p=0.019). In the subgroup with TG <200 mg/dL, subjects with circulating RBP4 above the median 46 mg/L had higher levels of intermediate density lipoprotein-cholesterol (IDL-C), low-density lipoprotein-cholesterol (LDL-C) and apolipoprotein B (ApoB), while these differences were absent in patients with TG ≥200 mg/dL. The associations of percentage changes of circulating RBP4 with the percentage changes of LDL-C, very low-density lipoprotein-cholesterol (VLDL-C) and ApoB were positive after the first month and 3 months of diet for patients with baseline TG <200 mg/dL, while no correlations existed for patients with TG ≥200 mg/dL. CONCLUSIONS: The positive association between circulating RBP4 and ApoB-containing lipoproteins in a steady metabolic state, as well as during a hypocaloric diet, appears to be attenuated in patients with very high TG.

Key words

Apolipoprotein B Diet Obesity Retinol-binding protein 4 Triglycerides 


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Copyright information

© Hellenic Endocrine Society 2016

Authors and Affiliations

  • Georgios A. Christou
    • 1
  • Constantinos C. Tellis
    • 2
  • Moses S. Elisaf
    • 3
  • Alexandras D. Tselepis
    • 2
  • Dimitrios N. Kiortsis
    • 1
    Email author
  1. 1.Laboratory of Physiology, Medical SchoolUniversity of IoanninaIoanninaGreece
  2. 2.Laboratory of Biochemistry, Department of ChemistryUniversity of IoanninaIoanninaGreece
  3. 3.Department of Internal Medicine, Medical SchoolUniversity of IoanninaIoanninaGreece

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