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Lipid accumulation product is associated with metabolic syndrome in women with polycystic ovary syndrome

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OBJECTIVE: There is a need for a simple and accurate method for the assessment of cardiovascular risk in polycystic ovary syndrome (PCOS). Lipid accumulation product (LAP) is based on the assessment of waist circumference and serum triglycerides that yield an estimation of lipid overaccumulation. We aimed to determine whether LAP is associated with metabolic syndrome (MetS) in Caucasian women with PCOS. DESIGN: We studied 222 women with PCOS who were diagnosed using the Rotterdam criteria. In all the subjects and controls, LAP was determined and the MetS was assessed using three different international criteria, NCEP-ATP III, IDF, and JIS. ROC curve and logistic regression analyses were performed to determine and analyze associations with the MetS. RESULTS: In the study population the prevalence of MetS was 16.2–19.4%. The cut-off value of 25.9 determined that LAP has the strongest association with MetS whichever international criteria are used, followed by HDL (NCEP-ATP III and JIS) and glucose (IDF). CONCLUSIONS: LAP is used as an independent clinical indicator for MetS in our PCOS women of Caucasian origin. The high diagnostic accuracy of LAP is superseding the need for the use of multiple clinical indicators for the assessment of lipid accumulation as a prerequisite for diagnosis of metabolic and cardiovascular diseases in PCOS women.

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Correspondence to Djuro Macut MD, PhD.

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Macut, D., Božić Antić, I., Bjekić-Macut, J. et al. Lipid accumulation product is associated with metabolic syndrome in women with polycystic ovary syndrome. Hormones 15, 35–44 (2016). https://doi.org/10.1007/BF03401401

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Key words

  • Lipid accumulation product
  • Metabolic syndrome
  • Polycystic ovary syndrome
  • Triglycerides
  • Waist circumference