, Volume 13, Issue 2, pp 244–251 | Cite as

Endothelial progenitor cells as a cardiometabolic risk factor marker in prediabetes

  • Angeliki AngelidiEmail author
  • Andreas Melidonis
  • Ioannis Protopsaltis
  • Theodoros N. Sergentanis
  • Angelos Gritzapis
  • Ioannis Kornezos
  • Theofanis Economopoulos
  • George Dimitriadis
  • Eleni Boutati
  • Sotirios A. Raptis
Research paper


OBJECTIVE: Endothelial progenitor cells (EPCs) have recently been considered as a potential novel marker of vascular integrity, atherosclerosis and cardiovascular risk. This study was performed to investigate the main determinants of EPC levels in individuals with prediabetes. DESIGN: Thirty-nine participants with newly diagnosed prediabetes were enrolled. Flow cytometric analysis was used to quantify EPCs (CD34 + CD133 + VEGFR-2+). Traditional risk factors, high-sensitivity C-reactive protein (hs-CRP), homeostasis model assessment of insulin resistance (HOMA-IR) and anthropometric parameters, including ultrasonographic-determined visceral and subcutaneous fat, were recorded. RESULTS: In univariate analysis, EPC levels significantly correlated with waist circumference (p = 0.017), mean arterial pressure (p = 0.009), total cholesterol (p = 0.003), hs-CRP (p = 0.006), HOMA-IR (p = 0.031) and visceral fat (p = 0.040). However, in stepwise multivariate ordinal logistic regression analysis, only visceral fat retained its statistical significance (OR=0.79, 95%Cl:0.64–0.98, p = 0.032). CONCLUSIONS: Visceral fat seems to be the main determinant of EPC levels in individuals with prediabetes and to form a plausible link between mild metabolic abnormalities, cardiovascular risk and vascular homeostasis process.

Key words

Endothelial progenitor cells Insulin resistance Prediabetes Visceral fat 


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Copyright information

© Hellenic Endocrine Society 2014

Authors and Affiliations

  • Angeliki Angelidi
    • 1
    Email author
  • Andreas Melidonis
    • 1
  • Ioannis Protopsaltis
    • 1
  • Theodoros N. Sergentanis
    • 2
  • Angelos Gritzapis
    • 3
  • Ioannis Kornezos
    • 4
  • Theofanis Economopoulos
    • 5
  • George Dimitriadis
    • 5
  • Eleni Boutati
    • 5
  • Sotirios A. Raptis
    • 5
    • 6
  1. 1.Diabetes Center“Tzaneio” General Hospital of PiraeusKeratsini, PiraeusGreece
  2. 2.Department of Epidemiology and BiostatisticsAthens University Medical SchoolAthensGreece
  3. 3.Department of PathologyLocus-Medicus SAAthensGreece
  4. 4.Department of Radiology“Tzaneio” General Hospital of PiraeusPiraeusGreece
  5. 5.2nd Department of Internal Medicine, Research Institute and Diabetes Center, “Attikon” University HospitalAthens University Medical SchoolAthensGreece
  6. 6.Hellenic National Center for ResearchPrevention and Treatment of Diabetes Mellitus and its Complications (H.N.D.C.)AthensGreece

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