Annual increase in the frequency of papillary thyroid carcinoma as diagnosed by fine-needle aspiration at a cytology unit in Sicily
- 1 Downloads
An increased frequency of papillary thyroid carcinoma (PTC) has been reported in the literature, including studies based on fine-needle aspiration cytology (FNAC).
To substantiate our own ascertainment of such an increase, we retrieved all the diagnoses of ultrasound-guided FNAC which was performed on 11,389 patients referred for cytological evaluation of a single or dominant thyroid nodule from 1988 to 2010. FNAC yielded 11,258 adequate specimens.
The number of patients with PTC was 200 (age 10–83 yrs) and increased significantly from 1988 to 2010 (r= 0.916, P<0.001). Expressing data as percent of FNAC in any given year, PTC and colloid goiter increased, while adenomatous goiter, follicular lesions and anaplastic or medullary thyroid cancer decreased. PTC accounted for 0% of all FNAC diagnoses in 1988 but for 2% in 2010, with a peak of 2.6% in 2006. Of interest, chronic lymphocytic thyroiditis (CLT) also increased, preceding the increase of PTC by 5–6 years.
We conclude that in the regions on either side of the Strait of Messina (Italy), PTC has become progressively more frequent during the 23-year period between 1988 and 2010 and that this increase lagged behind the increase of CLT.
Key wordsFine-needle aspiration cytology Papillary thyroid carcinoma Thyroid cancer
Unable to display preview. Download preview PDF.
- 4.Mittendorf EA, McHenry CR 2004 Thyroid cancer. In: Cameron JL, ed. Current Surgical therapy. 8th ed. Philadelphia, Pa: Elsevier Mosby; pp, 584–591.Google Scholar
- 5.Rago T, Fiore E, Scutari M, et al, 2010 Male sex, single nodularity, and young age are associated with the risk of finding a papillary thyroid cancer on fine-needle aspiration cytology in a large series of patients with nodular thyroid disease. Eur J Endocrinol 162: 763–770.CrossRefPubMedGoogle Scholar
- 22.British Thyroid Association. Guidelines for the management of thyroid cancer in adults. London: Royal College of Physicians of London and the British Thyroid Association, 2002. Available from URL: https://doi.org/www.british-thyroid-association.org/Google Scholar
- 23.Gharib H, Papini E, Valcavi R, et al; AACE/AME Task Force on Thyroid Nodules, 2006 American Association of Clinical Endocrinologists and Associazione Medici Endocrinologi medical guidelines for clinical practice for the diagnosis and management of thyroid nodules. Endocr Pract 12: 63–102.CrossRefPubMedGoogle Scholar
- 30.Sarlis NJ, Benvenga S 2004 Molecular signaling in thyroid cancer. In: Molecular basis of thyroid cancer. Farid NR (ed). Kluwer Academic Publishers, Boston; pp, 237–264.Google Scholar
- 31.Asa SL 2004 The pathology of thyroid cancer. In: Molecular basis of thyroid cancer. Farid NR (ed). Kluwer Academic Publishers, Boston; pp, 23–67.Google Scholar