, Volume 9, Issue 3, pp 269–273 | Cite as

Optic neuropathy following radiotherapy for Cushing’s disease: case report and literature review

  • Nikiforos Ballian
  • Ioannis I. Androulakis
  • Klio Chatzistefanou
  • Christianna Samara
  • Konstantinos Tsiveriotis
  • Gregory A. Kaltsas
Case report


Radiation-induced optic neuropathy is a rare adverse effect of radiotherapy applied for the treatment of pituitary adenomas. We report a patient with a recurrent adrenocorticotrophin secreting pituitary adenoma who received external beam irradiation after failing surgical and medical therapy. Sixteen months after radiotherapy, the patient was presented with declining visual acuity, and radiation-induced optic neuropathy was diagnosed. Despite treatment with glucocorticoids and hyperbaric oxygen, her vision did not improve. The pathophysiology, prevention and treatment of radiation-induced optic neuropathy, including the efficacy of hyperbaric oxygen therapy are reviewed.

Key words

Hyperbaric oxygen Optic neuropathy Pituitary adenoma Radiotherapy 


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Copyright information

© Hellenic Endocrine Society 2010

Authors and Affiliations

  • Nikiforos Ballian
    • 1
  • Ioannis I. Androulakis
    • 2
  • Klio Chatzistefanou
    • 3
  • Christianna Samara
    • 4
  • Konstantinos Tsiveriotis
    • 5
  • Gregory A. Kaltsas
    • 5
  1. 1.Department of SurgeryUniversity of WisconsinMadisonUSA
  2. 2.Department of Endocrinology and Diabetes CenterGeneral Hospital of Athens “G. Gennimatas”AthensGreece
  3. 3.Department of OphthalmologyGeneral Hospital of Athens “G. Gennimatas”AthensGreece
  4. 4.Department of RadiologyGeneral Hospital of Athens “G. Gennimatas”AthensGreece
  5. 5.Department of PathophysiologyUniversity of AthensAthensGreece

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