Interceram - International Ceramic Review

, Volume 64, Issue 8, pp 358–362 | Cite as

Synthesis and Properties of Hydroxyapatite Nanorods

  • A. A. KhalilEmail author
  • M. F. Zawrah
  • E. A. Saad
  • H. A. Badr
High-Performance Ceramics


Hydroxyapatite (HA) nanopowders were synthesized at 70°C by a co-precipitation method using slaked lime and phosphoric acid solution at different pH values. Ammonia was used to adjust the pH of the aquatic media during synthesis. The prepared powders were dried overnight at 100°C and characterized for their phase composition using Fourier transform infrared spectroscopy (IR) and X-ray diffraction (XRD). Selected powder prepared at pH 11 was used for some investigations for its microstructural features as elucidated by transmission and scanning electron microscopy (TEM, SEM) and then sintered at different temperatures from 1000 to 1250°C to determine its bulk density and apparent porosity of sintered bodies. Results indicated that hydroxyapatite nanopowder was successfully prepared by co-precipitation. A dense microstructure with grain growth of the hydroxyapatite was detected when its sintering temperature was increased. The prepared hydroxyapatite was thermally stable upon heating up to 1100°C; whereas above 1100°C it was slightly dissociated into β-tricalcium phosphate (β-TCP) and CaO. At 1200°C the β-tricalcium phosphate (β-TCP) formed was converted to the α-tricalcium phosphate phase (α-TCP), which was again reconverted to hydroxyapatite and almost dissociated at 1250°C.


hydroxyapatite synthesis precipitation nanorods sintering 


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  1. [1]
    Williams, D.F.: The Williams dictionary of biomaterials. Liverpool University Press, Liverpool, UK, (1999) 368–337Google Scholar
  2. [2]
    Aoki, H.: Science and medical applications of hydroxyapatite. Takayama Press, Tokyo, Japan, (1991)Google Scholar
  3. [3]
    Driessens, F.C.M. (Ed.).: Bioceramics of calcium phosphates. CRC Press, Boca Raton, FL, (1983)Google Scholar
  4. [4]
    Prashant, K.N., Sfeir, C., Lee, D.H., Olton, D., Choi, D.: Nanostructured calcium phosphates for biomedical applications: Novel synthesis and characterization. Acta Biomaterialia 1 (2005) 65–83CrossRefGoogle Scholar
  5. [5]
    Elliott J.C.: Structure and chemistry of the apatites and other calcium orthophosphate. Elsevier, Amsterdam, London (1994)Google Scholar
  6. [6]
    Rodriguez-Lorenzo, L.M., Vallet-Regi, M., Ferreira, J.M.F.: Fabrication of hydroxyapatite bodies by uniaxial pressing from a precipitated powder. Biomaterials 22 (2001) 583–588CrossRefGoogle Scholar
  7. [7]
    Suchanek, W., Yoshimura, M.: Processing and properties of hydroxyapatite: Based biomaterials for use as hard tissue replacement implants. J. Mater. Res. 13 (1998) [1] 94–117CrossRefGoogle Scholar
  8. [8]
    Kanazawa, T.: Hydroxyapatite. In: Inorganic phosphate materials. Materials Science Monographs, Elsevier, Tokyo, 52 (1989) 30Google Scholar
  9. [9]
    Hench, L.L.: Bioceramics: From concept to clinic. J. Am. Ceram. Soc. 74 (1991) 1487–1510CrossRefGoogle Scholar
  10. [10]
    Liu, Y., Hou, D., Wang, G.: A simple wet chemical synthesis and characterization of hydroxyapatite nanorods. Mater. Chem. and Phys. 86 (2004) 69–73CrossRefGoogle Scholar
  11. [11]
    Kim, W., Zhang, Q.W., Saito, F.: Mechanochemical synthesis of hydroxyapatite from Ca(OH)2-P2O5 and CaO-Ca(OH)2-P2O5. J. Mater. Sci. 35 (2000) 5401–5405CrossRefGoogle Scholar
  12. [12]
    Tas, A.C.: Combustion synthesis of calcium phosphate bioceramic powders. J. Eur. Ceram. Soc. 20 (2000) 2389–2394CrossRefGoogle Scholar
  13. [13]
    Jarcho, M., Bolen, C.H., Thomas, M.B., Bobick, J., Kay, J.F., Doremus, R.H.: Hydroxyapatite synthesis and characterization in dense polycrystalline form. J. Mater. Sci. 11 (1976) 2027–2035CrossRefGoogle Scholar
  14. [14]
    Huang, L.Y., Xu, K.W., Lu, J.: A study of the process and kinetics of electrochemical deposition and the hydrothermal synthesis of hydroxyapatite coatings. J. Mater. Sci. Mater. Med. 11 (2000) 667–673CrossRefGoogle Scholar
  15. [15]
    Weng, W.J., Baptista, J.L.: Alkoxide route for preparing hydroxyapatite and its coatings. Biomaterials 19 (1998) 125–131CrossRefGoogle Scholar
  16. [16]
    Katsuki, H., Furuta, S., Komarneni, S.: Microwave versus conventional hydrothermal synthesis of hydroxyapatite crystals from Gypsum. J. Am. Ceram. Soc. 82 (1999) 2257–2259CrossRefGoogle Scholar
  17. [17]
    Lim, G.K., Wang, J., Ng, S.C., Gan, L.M.: Formation of nanocrystalline hydroxyapatite in non-ionic surfactant emulsions. Langmuir 15 (1999) 7472–7477CrossRefGoogle Scholar
  18. [18]
    Pang, Y.X., Bao, X.: Influence of temperature, ripening time and calcination on the morphology and crystallinity of hydroxyapatite nanoparticles. J. Eur. Ceram. Soc. 23 (2003) 1697–1704CrossRefGoogle Scholar
  19. [19]
    Varma, H.K., Babu, S.S.: Synthesis of calcium phosphate bioceramics by citrate gel pyrolysis method. Ceram. Int. 31 (2005) 109–114CrossRefGoogle Scholar
  20. [20]
    Joris, S.J., Amberg, C.H.: Nature of deficiency in nonstoichiometric hydroxyapatites. II. Spectroscopic studies of calcium and strontium hydroxyapatites. J. Phys. Chem. 75 (1971) 3172–3178CrossRefGoogle Scholar
  21. [21]
    Fowler, B.O.: Infrared spectra of apatite. In: W.E. Brown, R.A. Young (Eds.), International Symposium on Structural Properties of Hydroxyapatite and Related Compounds, Chapter 7, Gaithersburg, MD, (1968), unpublished, but copies of Chapter 7 are available from B.O. FowlerGoogle Scholar
  22. [22]
    Ishikawa, T., Wakamura, M., Kondo, S.: Surface characterization of calcium hydroxylapatite by Fourier transform infrared spectroscopy. Langmuir 5 (1989) 140–144CrossRefGoogle Scholar
  23. [23]
    Monma, H., Ueno, S., Kanazawa, T.: Properties of hydroxyapatite prepared by the hydrolysis of tricalcium phosphate. J. Chem. Tech. Biotechnol. 31 (1981) 15–24CrossRefGoogle Scholar
  24. [24]
    Bouyer, E., Gitzhofer, F., Boulos, M.I.: Morphological study of hydroxyapatite nanocrystal suspension. J. Mater. Sci. Mater. Med. 11 (2000) 523–531CrossRefGoogle Scholar
  25. [25]
    Fathi, M.H., Hanifia, A., Mortazavi, V.B.: Preparation and bioactivity evaluation of bone-like hydroxyapatite nanopowder. J. Mater. Proc. Tech. 202 (2008) 536–542CrossRefGoogle Scholar
  26. [26]
    Ryu, H.S., Youn, H.J., Hong, K.S., Chang, B.S., Lee, C.K., Chung, S.S.: An improvement in sintering property of β-tricalcium phosphate by addition of calcium pyrophosphate. Biomaterials 23 (2002) 909–914CrossRefGoogle Scholar
  27. [27]
    Wang, J., Shaw, L.: Morphology enhanced low temperature sintering of nanocrystalline hydroxyapatite. Adv. Mater. 19 (2007) [2] 364–369Google Scholar

Copyright information

© Springer Fachmedien Wiesbaden 2015

Authors and Affiliations

  • A. A. Khalil
    • 1
    Email author
  • M. F. Zawrah
    • 1
  • E. A. Saad
    • 2
  • H. A. Badr
    • 1
  1. 1.Ceramics DepartmentNational Research CenterDokki, CairoEgypt
  2. 2.Chemistry Department, Faculty of ScienceAin Shams UniversityCairoEgypt

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