Fluoride and the caries lesion: interactions and mechanism of action
- 283 Downloads
AIM: To review the mechanisms of action of fluoride (F). METHODS: Narrative review of the literature. FINDINGS: Fluoride can reduce tooth mineral solubility by exchanging for hydroxyl groups and reducing carbonate content. Thus its presence in solution facilitates mineral precipitation or reprecipitation by lowering solubility products of precipitating calcium phosphates. While sound enamel tends to lose fluoride with age, it accumulates at stagnation sites where caries lesions develop indicating this as a site of action. Fluoride in the lesion will encourage remineralisation [Robinson et al., 2000] such that penetration of the lesion by fluoride is pivotal. Access from plaque, however, is limited due to restricted penetration. CONCLUSIONS: Maintaining a very thin plaque layer is thus important in delivering fluoride to the lesion.
Key wordsCaries-lesions chemistry
Unable to display preview. Download preview PDF.
- Boyde A. Enamel. In: Handbook of microscopic anatomy. Oksche A, Vollrath L, editors. Berlin: Springer Verlag, 1989 pp. 309–473.Google Scholar
- Darling AI. Studies of the early lesion of enamel caries with transmitted light, polarised light and radiography. Br Dent J, 1956; 101: 289–297.Google Scholar
- Hallsworth AS, Robinson C, Weatherell JA. Loss of carbonate during the first stages of enamel caries Caries Res 1973; 7: 345–348.Google Scholar
- Kreinbrink AT, Sazavsky CD, Pyrz JW, Nelson DGA, Honkonen RS. Fast magic angle spinning 19F NMR of inorganic fluorides and fluoridated apatitic surfaces. Magn Reson 1990; 88: 267–276.Google Scholar
- LeGeros RZ. Incorporation of magnesium in synthetic and in biological apatites. In: Tooth Enamel IV, 1984; Fearnhead RW, Suga S, editors. Amsterdam: Elsevier, pp. 32–36.Google Scholar
- Robinson C, Kirkham J, Brookes SJ, Shore RC. Chemistry of mature enamel. In: Dental enamel: formation to destruction. Robinson C, Kirkham J, Shore RC, editors. Bca Raton: CRC Press, 1995 pp. 167–191.Google Scholar
- Robinson C, Watson PS., Penetration of therapeutic agents through natural plaque biofilms. In Biofilms, Persistence and Ubiquity, 2005. The Biofilm, Club, Eds. Mcbain, A, Allison D, Pratten J; 343–353.Google Scholar
- Rølla G, Ogaard B., How important is CaF2 in the cariostatic mechanism of fluoride in vivo. In: Factors relating to the demineralisation and remineralisation of teeth. Leach SA, editor. Oxford: IRL Press, 1986; pp. 45–50.Google Scholar
- Young RA. Biological apatite vs. hydroxyapatite at the atomic level. Clin Orthop 1975;113:249–262.Google Scholar