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Bronchial artery chemotherapy for inoperable non-small-cell lung cancer


We applied low-dose cisplatin regimen delivered by an interventional method to twenty-one consecutively treated patients with inoperable NSCLC. The regimen consisted of cisplatin SO mg/m2, mitomycin C 10 mg/m2, and 5-Fu 500 mg/m2. All patients had positive response to the treatment. The overall response rate was 76.2% (CR: 23.8%, PR: 52.4%). The median survival was 25.5±3.2 weeks, which was similar to those obtained by other combination chemotherapies, but the toxicity was significantly reduced. The results suggested that bronchial artery chemotherapy would give the patients with advanced NSCLC a satisfactory early results and a higher quality of life. It is advisable to select bronchial artery chemotherapy as a preoperative treatment for advanced NSCLC.

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  1. 1.

    Hoffman PC, Bitran JD, Golomb HM. Chemotherapy of metastatic non-small-cell lung cancer. Semin Oncol 1983; 10:111.

  2. 2.

    Dhingra HM, Valdivieso M, Carr DT, et al. Randomized trial of three combination of cisplatin with vindesine and/or VP16-213 in treatment of advanced non-small-cell lung cancer. J Clin Oncol 1985; 3: 176.

  3. 3.

    Klastersky J, Sculier JP. Chemotherapy of non-small-cell lung cancer. Semin Oncol 1985; 12:38.

  4. 4.

    Rapp E, Pater JL, Willan A, et al. Chemotherapy can prolong survival in patients with advanced non-small-cell lung cancer—Report of a Canadian multicenter randomized trial. J Clin Oncol 1988; 6:633.

  5. 5.

    Woods RL, Williams CJ, Levi J, et al. A randomized trial of cisplatin and vindesine versus supportive care only in advanced non-small-cell lung cancer. Br J Cancer 1990; 61:608.

  6. 6.

    Burk RL, Ginsberg RJ, Shepherd FA, et al. Induction chemotherapy with mitomycin, vindesine, and cisplatin for stage III unresectable non-small-cell lung cancer: Results of Toronto phase II trial. J Clin Oncol 1992; 10:580.

  7. 7.

    Liu ZJ, Xu SX, Han XN, et al. Selective bronchial artery perfusion with cisplatin in the treatment of inoperable bronchogenic carcinoma. Chinese J Radiology 1987; 21:4.

  8. 8.

    Pang QQ, Li CL, Zeng W, et al. Results of bronchial artery chemotherapy infusion for lung cancer—Report of 82 cases. Chinese J Oncology 1989; 11:60.

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Correspondence to Zequan Yang.

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Yang, Z., Yang, Y., Liu, W. et al. Bronchial artery chemotherapy for inoperable non-small-cell lung cancer. Chin J Cancer Res 7, 219–224 (1995).

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Key words

  • Interventional
  • Lung cancer
  • Bronchial artery