Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Non-opioid strategies for acute pain management

  • 867 Accesses

  • 13 Citations


Subscribers to the Canadian Journal of Anesthesia are invited to read the following article to introduce them to a number of key articles cited in the bibliography. Reading at least the articles preceded by an asterisk (*) allows adequate preparation for the Self-Assessment Program, which can be completed by accessing the Continuing Medical Education (CME) link on the Journal site (http://www.cja-jca.org). Completion of the Self-Assessment Program will entitle subscribers to claim up to ten hours of Continuing Professional Development (CPD) under section 3 ofCPD options, for a total of up to 20 Maintenance of Certification credits (note that section 3 hours are not limited to a maximum number of credits per five-year period). Obtaining CME credits for this module is not based upon attaining a specific score: the goal of participating is to define potential areas for improvement.


  1. 1

    Goldstein DH, VanDenKerkhof EG, Blaine WC. Acute pain management services have progressed, albeit insufficiently in Canadian academic hospitals. Can J Anesth 2004; 51:231–5.

  2. *2

    White PF. The changing role of non-opioid analgesic techniques in the management of postoperative pain. Anesth Analg 2005; 101(5 Suppl): S5–22.

  3. * 3

    Power I. Recent advances in postoperative pain therapy. Br J Anaesth 2005; 95: 43–51.

  4. 4

    Langford RM. Pain management today - what have we learned? Clin Rheumatol 2006; 25(Suppl 7): 2–8.

  5. *

    5 Marret E, Kurdi O, Zufferey P, Bonnet F. Effects of nonsteroidal antiinflammatory drugs on patient-controlled analgesia morphine side effects: meta-analysis of randomized controlled trials. Anesthesiology 2005; 102: 1249–60.

  6. 6

    Topol EJ. Arthritis medicines and cardiovascular events — “house of coxibs”. JAMA 2005; 293: 366–8.

  7. 7

    Nussmeier NA, Whelton AA, Brown MT, et al. Complications of the COX-2 inhibitors parecoxib and valdecoxib after cardiac surgery. N Engl J Med 2005; 352: 1081–91.

  8. *8

    Bainbridge D, Cheng DC, Martin JE, Novick R; Evidence-Based Perioperative Clinical Outcomes Research (EPiCOR) Group. NSAID-analgesia, pain control and morbidity in cardiothoracic surgery. Can J Anesth 2006; 53: 46–59.

  9. 9

    Harris RC. COX-2 and the kidney. J Cardiovasc Pharmacol 2006; 47(Suppl 1): S37–42.

  10. *10

    Reuben SS, AblettD, Kaye R. High dose nonsteroidal anti-inflammatory drugs compromise spinal fusion. Can J Anesth 2005; 52: 506–12.

  11. 11

    Alhashemi JA, Alotaibi QA, Mashaat MS, Kaid TM, Mujallid RH, Kaki AM. Intravenous acetaminophen vs oral ibuprofen in combination with morphine PCIA after cesarean delivery. Can J Anesth 2006; 53: 1200–6.

  12. 12

    Romsing J, Moiniche S, Dahl JB. Rectal and parenteral paracetamol, and paracetamol in combination with NSAIDs, for postoperative analgesia. Br J Anaesth 2002; 88: 215–26.

  13. 13

    Hyllested M, Jones S, Pedersen JL, Kehlet H Comparative effect of paracetamol, NSAIDs or their combination in postoperative pain management: a qualitative review. Br J Anaesth 2002; 88: 199–214.

  14. 14

    Remy C, Marret E, Bonnet F. Effects of acetaminophen on morphine side-effects and consumption after major surgery: meta-analysis of randomized controlled trials. Br J Anaesth 2005; 94: 505–13.

  15. *15

    Boezaart AP. Perineural infusion of local anesthetics. Anesthesiology 2006; 104: 872–80.

  16. 16

    Ilfeld BM, Enneking FK. Continuous peripheral nerve blocks at home: a review. Anesth Analg 2005; 100: 1822–33.

  17. 17

    Cereda CM, Brunetto GB, de Araujo DR, de Paula E. Liposomal formulations of prilocaine, lidocaine and mepivacaine prolong analgesic duration. Can J Anesth 2006; 53: 1092–7.

  18. 18

    Batra YK, Mahajan R, Bangalia SK, Nagi ON, Dhillon MS. Bupivacaine/ketamine is superior to intra-articular ketamine analgesia following arthroscopic knee surgery. Can J Anesth 2005; 52: 832–6.

  19. 19

    Karamanlioglu B, Turan A, Memis D, Kaya G, Ozata S, Ture M. Infiltration with ropivacaine plus lornoxicam reduces postoperative pain and opioid consumption. Can J Anesth 2005; 52: 1047–53.

  20. *20

    Gilron I. Review article: the role of anticonvulsant drugs in postoperative pain management: a bench-to-bedside perspective. Can J Anesth 2006; 53: 562–71.

  21. 21

    Al-Mujadi H, A-Refai AR, Katzarov MG, Dehrab NA, Batra YK, Al-Qattan AR. Preemptive gabapentin reduces postoperative pain and opioid demand follow- ing thyroid surgery. Can J Anesth 2006; 53: 268–73.

  22. 22

    Pandey CK, Sahay S, Gupta D, et al. Preemptive gaba-pentin decreases postoperative pain after lumbar discoidectomy. Can J Anesth 2004; 51: 986–9.

  23. *23

    Seib RK, Paul JE. Preoperative gabapentin for postoperative analgesia: a meta-analysis. Can J Anesth 2006; 53: 461–9.

  24. *24

    Lebrun T, Van Elstraete AC, Sandefo I, Polin B, Pierre-Louis L. Lack of a pre-emptive effect of low-dose ketamine on postoperative pain following oral surgery. Can J Anesth 2006; 53: 146–52.

  25. 25

    McCartney CJ, Sinha A, Katz J. A qualitative systematic review of the role of N-methyl-D-aspartate receptor antagonists in preventive analgesia. Anesth Analg 2004; 98: 1385–400.

  26. 26

    Elia N, Tramer MR. Ketamine and postoperative pain - a quantitative systematic review of randomised trials. Pain 2005; 113: 61–70.

  27. 27

    Brill S, Plaza M. Non-narcotic adjuvants may improve the duration and quality of analgesia after knee arth-roscopy: a brief review. Can J Anesth 2004; 51: 975–8.

  28. 28

    Habib AS, Gan TJ. Use of neostigmine in the management of acute postoperative pain and labour pain: a review. CNS Drugs 2006; 20: 821–39.

  29. 29

    Durieux ME. Peripheral analgesic receptor systems. Br J Anaesth 2006; 97: 273–4.

  30. 30

    Dube L, Granry JC. The therapeutic use of magnesium in anesthesiology, intensive care and emergency medicine: a review. Can J Anesth 2003; 50: 732–46.

  31. 31

    Beaulieu P. Effects of nabilone, a synthetic cannabi-noid, on postoperative pain. Can J Anesth 2006; 53: 769–75.

Download references

Author information

Correspondence to Pierre Beaulieu.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Beaulieu, P. Non-opioid strategies for acute pain management. Can J Anesth 54, 481 (2007). https://doi.org/10.1007/BF03022036

Download citation


  • Morphine
  • Rofecoxib
  • Ketorolac
  • Continue Medical Education
  • Etoricoxib