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The genetic aspects of anaesthesiology


It is certain that the various reactions noted, even those that show most clearly a hereditary factor, are not pure, which means that they contain an element of exogenous variability. We shall broaden the study, in order to find all the possible endogenous variants and in order to isolate the specific element of the genotype susceptible to the anaesthetic drugs. However, the value of the psychological response of the patients to general anaesthesia is satisfactory from the genetic point of view, because the method that we used seems to be the best for isolating the reactions and for finding the family element, in this case hereditary. From the anaesthetic point of view, we would like to say that the method that we used to analyse the psychosomatic reactions to general anaesthesia is quite similar to the method used to test the anaesthetic drugs. This genetic interpretation of anaesthesia would be of practical help to anaesthesia itself. From the data obtained from our research, a practical anaesthesia problem came to our mind: “Will the ànaesthesiologist be able to make the right choice of anaesthesia and to avoid anaesthetic complications in an anaesthetized patient? Will he able to do so when he knows the problems that the patient’s relatives have had previously during anaesthesia?” We cannot answer these questions yet, but we are undertaking another research project in which we are trying to find the true cause of the various reactions, keeping in our mind the value of all the possible variants.


  1. 1.

    Gedda, L., &Rizzi, R. Genetica e anestesia (nota peventiva). Acta Gen. Med. Gem.8: 125–34 (1959).

  2. 2.

    Gedda, L.;Rezzi, R.; &Gagliardi, B. Reaktionen des plurinarkotisierten Individuums. Der Anaesthetist9: 144–7 (1960).

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Correspondence to L. Gedda or R. Rizzi.

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Read at the Second World Congress of Anaesthesiologists in Toronto, September, 1961.

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Gedda, L., Rizzi, R. The genetic aspects of anaesthesiology. Can. Anaes. Soc. J. 9, 26–35 (1962).

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  • Anaesthetic Drug
  • Genetic Aspect
  • Psychological Reaction
  • Fluothane
  • Control Couple