Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Allergies to local anesthetics — the real truth

Les allergies aux anesthésiques locauxla vraie vérité

  • 673 Accesses

  • 27 Citations


  1. 1

    Koller C. Historical notes on the beginning of local anesthesia. JAMA 1928; 90: 1742–43.

  2. 2

    Eggleston C, Hatcher RA. A further contribution to the pharmacology of the local anesthetics. J Phamacol Exp Ther 1919; 13: 433–87.

  3. 3

    Braun H. Üeber einge neue örtliche Anästhetika (Stovain, Alypin, Novocain), Dtsch Med Wochenschr 1905; 2: 1667–71.

  4. 4

    Mook WH. Skin reactions to apothesin and quinine (sic) in susceptible persons. Arch Dermatol 1920; 1: 651–5.

  5. 5

    Löfgren N. Studies on Local Anesthetics. Xylocaine: a New Synthetic Drug. Stockholm: Hoeggstroms; 1948.

  6. 6

    Assent ES, Punnia-Moorthy A. Allergy to local anaesthetics: an approach to definitive diagnosis. Br Dent J 1988; 164: 44–7.

  7. 7

    Brown DT, Beamish D, Wildsmith JA. Allergic reaction to an amide local anaesthetic. Br J Anaesth 1981; 53: 435–7.

  8. 8

    Wong DT, Gadsden JC. Acute upper airway angioedema secondary to acquired C1 esterase inhibitor deficiency: a case report. Can J Anesth 2003; 50: 900–3.

  9. 9

    Bacon GS, Lyons TR, Wood SH. Dyclonine hydrochloride for airway anesthesia: awake endotracheal intubation in a patient with suspected local anesthetic allergy. Anesthesiology 1997; 86: 1206–7.

  10. 10

    Matthey P, Finegan BA, Finucane BT. The attitude of the general public towards regional anesthesia. Reg Anesth Pain Med 2004 (in press).

  11. 11

    Kozody R, Ready LB, Barsa JE. Dose requirement of local anesthetic to produce grand mal seizure during stellate ganglion block. Can Anaesth Soc J 1982; 29: 489–91.

  12. 12

    Rae SM, Milne MK, Wildsmith JA. Anaphylaxis associated with, but not caused by, extradural bupivacaine. Br J Anaesth 1997; 78: 224–6.

  13. 13

    de Jong RH. Local Anesthetics, 2nd ed. St Louis: MO; Mosby-Year Book Inc.; 1994.

  14. 14

    Tetzlaff JE. Clinical Pharmacology of Local Anesthetics, 1st ed. Boston: Butterworth-Heinemann; 2000.

  15. 15

    Balestrieri PJ, Ferguson JE II. Management of a parturient with a history of local anesthetic allergy. Anesth Analg 2003; 96: 1489–90.

  16. 16

    Chandler MJ, Grammer LC, Patterson R. Provocative challenge with local anesthetics in patients with a prior history of reaction. J Allergy Clin Immunol 1987; 79: 883–6.

Download references

Author information

Correspondence to Brendan T. Finucane.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Finucane, B.T. Allergies to local anesthetics — the real truth. Can J Anesth 50, 869–874 (2003). https://doi.org/10.1007/BF03018730

Download citation