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Xenon anesthesia: safe, protective and neurotoxic?

L’anesthésie au xénon: sécuritaire, protectrice et neurotoxique?

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References

  1. 1

    Cullen SC, Gross EG. The anesthetic properties of xenon in animals and human beings, with additional observations on krypton. Science 1951; 113: 580–2.

  2. 2

    Franks NP, Dickinson R, de Sousa SL, Hall AC, Lieb WR. How does xenon produce anaesthesia? Nature 1998; 396: 324.

  3. 3

    Rossaint R, Reyle-Hahn M, Schulte am Esch J, et al.;Xenon Study Group. Multicenter randomized comparison of the efficacy and safety of xenon and isoflurane in patients undergoing elective surgery. Anesthesiology 2003; 98: 6–13.

  4. 4

    Goto T, Saito H, Shinkai M, Nakata Y, Ichinose F, Morita S. Xenon provides faster emergence from anesthesia than does nitrous oxide-sevoflurane or nitrous oxide-isoflurane. Anesthesiology 1997; 86: 1273–8.

  5. 5

    Ma D, Hossain M, Pettet GK, et al. Xenon preconditioning reduces brain damage from neonatal asphyxia in rats. J Cereb Blood Flow Metab 2006; 26: 199–208.

  6. 6

    Hobbs C, Thoresen M, Tucker A, Aquilina K, Chakkarapani E, Dingley J. Xenon and hypothermia combine additively, offering long-term functional and histopathologic neuroprotection after neonatal hypoxia/ischemia. Stroke 2008; 39: 1307–13.

  7. 7

    Cattano D, Williamson P, Fukui K, et al. Potential of xenon to induce or protect against neuroapotosis in the developing mouse brain. Can J Anesth 2008;55: 429–36.

  8. 8

    Jevtovic-Todorovic V, Hartman RE, Izumi Y, et al. Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits. J Neurosci 2003; 23: 876–82.

  9. 9

    Olney JW, Young C, Wozniak DF, Jevtovic-Todorovic V, Ikonomidou C. Do pediatric drugs cause developing neurons to commit suicide? Trends Pharmacol Sci 2004; 25: 135–9.

  10. 10

    Olney JW, Young C, Wozniak DF, Ikonomidou C, Jevtovic-Todorovic V. Anesthesia-induced developmental neuroapoptosis. Does it happen in humans? Anesthesiology 2004; 101: 273–5.

  11. 11

    Todd MM. Anesthetic neurotoxicity: the collision between laboratory neuroscience and clinical medicine. Anesthesiology 2004; 101: 272–3.

  12. 12

    Ikonomidou C, Bosch F, Miksa M, et al. Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain. Science 1999; 283: 70–4.

  13. 13

    Johnson SA, Young C, Olney JW. Isoflurane-induced neuroapoptosis in the developing brain of nonhypoglycemic mice. J Neurosurg Anesthesiol 2008; 20: 21–8.

  14. 14

    Jevtovic-Todorovic V, Beals J, Benshoff N, Olney JW. Prolonged exposure to inhalational anesthetic nitrous oxide kills neurons in adult rat brain. Neuroscience 2003; 122: 609–16.

  15. 15

    Lagasse RS. Anesthesia safety: model or myth? A review of the published literature and analysis of current original data. Anesthesiology 2002; 97: 1609–17.

  16. 16

    Cheney FW, Posner KL, Lee LA, Caplan RA, Domino KB. Trends in anesthesia-related death and brain damage: a closed claims analysis. Anesthesiology 2006; 105: 1081–6.

  17. 17

    Silverstein JH, Timberger M, Reich DL, Uysal S. Central nervous system dysfunction after noncardiac surgery and anesthesia in the elderly. Anesthesiology 2007; 106: 622–8.

  18. 18

    Karkouti K, Djaiani G, Borger MA, et al. Low hematocrit during cardiopulmonary bypass is associated with increased risk of perioperative stroke in cardiac surgery. Ann Thorac Surg 2005; 80: 1381–7.

  19. 19

    Coburn M, Kunitz O, Apfel CC, Hein M, Fries M, Rossaint R. Incidence of postoperative nausea and emetic episodes after xenon anaesthesia compared with propofol-based anaesthesia. Br J Anaesth 2008 [Epub ahead of print] PMID 1839792.

  20. 20

    Rex S, Meyer PT, Baumert JH, et al. Positron emission tomography study of regional cerebral blood flow and flow-metabolism coupling during general anaesthesia with xenon in humans. Br J Anaesth 2008; 100: 667–75.

  21. 21

    Bonin RP, Orser BA. GABA(A) receptor subtypes underlying general anesthesia. Pharmacol Biochem Behav 2008 [Epub ahead of print] PMID 18201756.

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Correspondence to Gregory M. T. Hare MD.

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Competing interests: None declared.

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Hare, G.M.T. Xenon anesthesia: safe, protective and neurotoxic?. Can J Anesth 55, 403 (2008). https://doi.org/10.1007/BF03016305

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