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Epidural and nerve block anaesthesia with sympocaine

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In all 413 patients were anaesthetized with Symoocaine 0.5 per cent without epinephrine. Most (175) of the blocks were cauda epidurals with a further 28 sacral and 41 thoraco-lumbar epidural anaesthetics. Possible toxic reactions were observed in 10 patients (2.5 per cent). Hypotension was noted in epidural type anaesthesia and was almost certainly related to the form of block. Temporary irritation occurred on intradermal injection in more than one-third of skin wheals, but this is considered to occur because the experimental solution contains 1:600 phenol. Onset is rapid, usually requiring 4’5 minutes, while duration of action varies between one and a half and two and a half hours. The most common doses for the several techniques are mentioned.

Sympocaine 0.5 per cent used in doses between 15 and 30, cc has been found to be reliable, to have moderate spreading ability, adequate effect and little evidence of toxic reaction.


Nous avons pratiqué, chez 413 malades, une anesthésie avec de la sympocaine 0.5 pour cent sans épinephrine. La plupart des blocages (175) ont consisté en des épidurales caudales et, dans 28 cas, en des sacrées et, dans 41 cas, en des épidurales thoraco-lombaires. Chez dix malades (2 5 pour cent), nous avons observé des réactions qui ont été, il est possible, des réactions toxiques. Au cours des anesthésies épidurales, nous avons observé de ľhypotension qui était sans doute attribuable à la sorte ďanesthésie. Dans 33 1/3 pour cent des injections intradermiques, nous avons observé une irritation temporaire, mais à noter que la solution expérimentale contenait 1.600 de phenol. Ľinduction de ľanesthésie est rapide ne réquérant ordinairement que 4 ou 5 minutes et la durée varie de 1 1/2 à 2 1/2 heures. La Sympocame 0.5 pour cent employé à des doses variant de 15 à 30 ml. s’est avérée constante ďaction, possédant un certain pouvoir de diffusion, assez efficace et laissant de légères traces de réaction toxique


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Correspondence to Max S. Sadove or Anthony P. Melgrave or Myron J. Levin.

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Sadove, M.S., Melgrave, A.P. & Levin, M.J. Epidural and nerve block anaesthesia with sympocaine. Can. Anaes. Soc. J. 5, 55–60 (1958). https://doi.org/10.1007/BF03015577

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  • Nerve Block
  • Nous Avons
  • Procaine
  • Tetracaine
  • Epidural Block