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Oral diazepam premedication reduces the incidence of post-succinylcholine muscle pains

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In a prospective, double-blind placebo controlled trial, the effect of oral diazepam premedication on post-succinylcholine fasciculations and myalgia was studied. Forty patients undergoing seploplasty procedures received orally identical capsules containing either 10 mg of diazepam or a placebo 90 minutes preoperatively. A standardized anaesthetic regimen included induction with 5 mg.kg-1 of thiopental and 1 mg.kg-1 of succinylcholine. The diazepam and control groups did not differ significantly in extent of fasciculations or ease of intubation, However, only 15 per cent of the diazepam premedicated patients had myalgias postoperatively compared to 50 per cent of the control patients, a statistically significant difference (p = 0.04).


On a réalisé une étude prospective à double-insu sur l’effet de la prémédication au diazépam par voie orale sur les fasciculations et les myalgies secondaires à l’administration de succinylcholine. Quarante patients subissant une septoplastie ont reçu 90 minutes avant l’opération, soit 10 mg de diazépam, soit un placebo de présentation identique. L’induction de l’anesthésie a été faite avec 5mg.kg-1 de thiopemal et. l mg.kg-1 de succinylcholine chez tous les patients.

Il n’y a pas eu de différence significative entre les deux groupes en ce qui concerne les fasciculalions et la facilité d’intubation. Cependant, seulement 15 pour cent des patients prémêdiqués au diazépam ont eu des myalgies dans la période post-opératoire comparativement à 50 pour cent pour les patients du groupe contrôle ce qui est statistiquement significatif (p = 0.04).


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Davies, A.O. Oral diazepam premedication reduces the incidence of post-succinylcholine muscle pains. Can Anaesth Soc J 30, 603 (1983). https://doi.org/10.1007/BF03015230

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Key words

  • Preanaesthetic medication: diazepam
  • Neuro-muscular relaxants: succinylcholine
  • adverse effects