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An enzymocytochemical study of alkaline phos-phatase isoenzymes in gastric cancer — Light and electron microscopic observations

Abstract

By using light and electron microscopic cytochemical technique, the activities and distributions of AP isoenzymes in gastric cancers and benign gastric diseases were examined. The results showed; Nagao, Regan and Kasahara isoenzymes, which were not expressed in normal gastric mucosae and non - malignant lesions, might be considered as tumor markers of gastric cancer; The epithelium of intestinal metaplasia exhibited intestinal -type AP only, which was one of the markers of well - differentiated intestinal metaplasia. In the view - point of the gene expression of AP isoenzymes, two mutation hypothesis and recessive - gene mutation hypothesis might be fit for gastric cancer.

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References

  1. 1.

    Fishman WH. Perspectives on alkaline pho-sphatase isoenzymes. Am J Med 1974; 56:617.

  2. 2.

    Takagi K, Meano M, Misumi A, et al. Studies on alkaline phosphatase isoenzyme in gastric carcinoma tissue. Gastroenter Jap 1981; 86:110.

  3. 3.

    Mayahara H, Hirano H, Saito T, et al. The new lead citrate method for the ultracytochemical demonstration of activity of non-specific alkaline phosphatase (orthophosphoric monoester phosphohydrolase). Histochemistry 1967; 11:88.

  4. 4.

    苏英豪, 杨光霖, 董明, 等. 碱性磷酸酶同功酶组化染色法 在胃癌研究中的应用. 临床与实验病理学杂志 1992; (4):312.

  5. 5.

    Miki K, Oda T, Suzuki H, et al. Alkaline phosphatase isoenzymes in intestinal metaplasia and carcinoma of the stomach. Cancer Res 1976; 36:4266.

  6. 6.

    Watanabe H, Tokuyama H, Ohta H, et al. Expression of placental alkaline phosphatase in gastric and colorectal cancers. An immunohistochemical study using the prepared monoclonal antibody. Cancer 1990; 66:2575.

  7. 7.

    1985;7(6):260.

  8. 8.

    Szentirmay Z, Sugar J, Kralovanszky J, et al. Early detection of human gastric cancer based on morphological and enzymologic studies. Cancer Detect Prev 1982; 5: 185.

  9. 9.

    Kralovanszky J, Szentirmay Z, Besznyak I, et al. Placental type alkaline phosphatase in possibly premalignant alterations of human gastric tissue. Oncology 1984; 41:189.

  10. 10.

    1992; 633–643.

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Correspondence to Yinghao Su.

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Su, Y., Yang, G., Dong, Y. et al. An enzymocytochemical study of alkaline phos-phatase isoenzymes in gastric cancer — Light and electron microscopic observations. Chin J Cancer Res 7, 141 (1995). https://doi.org/10.1007/BF03014412

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Key word

  • Alkaline phosphatase isoenzymes
  • Gastric cancer
  • Cytochemistry
  • Light microscopy
  • Electron microscopy