By using light and electron microscopic cytochemical technique, the activities and distributions of AP isoenzymes in gastric cancers and benign gastric diseases were examined. The results showed; Nagao, Regan and Kasahara isoenzymes, which were not expressed in normal gastric mucosae and non - malignant lesions, might be considered as tumor markers of gastric cancer; The epithelium of intestinal metaplasia exhibited intestinal -type AP only, which was one of the markers of well - differentiated intestinal metaplasia. In the view - point of the gene expression of AP isoenzymes, two mutation hypothesis and recessive - gene mutation hypothesis might be fit for gastric cancer.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Fishman WH. Perspectives on alkaline pho-sphatase isoenzymes. Am J Med 1974; 56:617.
Takagi K, Meano M, Misumi A, et al. Studies on alkaline phosphatase isoenzyme in gastric carcinoma tissue. Gastroenter Jap 1981; 86:110.
Mayahara H, Hirano H, Saito T, et al. The new lead citrate method for the ultracytochemical demonstration of activity of non-specific alkaline phosphatase (orthophosphoric monoester phosphohydrolase). Histochemistry 1967; 11:88.
苏英豪, 杨光霖, 董明, 等. 碱性磷酸酶同功酶组化染色法 在胃癌研究中的应用. 临床与实验病理学杂志 1992; (4):312.
Miki K, Oda T, Suzuki H, et al. Alkaline phosphatase isoenzymes in intestinal metaplasia and carcinoma of the stomach. Cancer Res 1976; 36:4266.
Watanabe H, Tokuyama H, Ohta H, et al. Expression of placental alkaline phosphatase in gastric and colorectal cancers. An immunohistochemical study using the prepared monoclonal antibody. Cancer 1990; 66:2575.
Szentirmay Z, Sugar J, Kralovanszky J, et al. Early detection of human gastric cancer based on morphological and enzymologic studies. Cancer Detect Prev 1982; 5: 185.
Kralovanszky J, Szentirmay Z, Besznyak I, et al. Placental type alkaline phosphatase in possibly premalignant alterations of human gastric tissue. Oncology 1984; 41:189.
About this article
Cite this article
Su, Y., Yang, G., Dong, Y. et al. An enzymocytochemical study of alkaline phos-phatase isoenzymes in gastric cancer — Light and electron microscopic observations. Chin J Cancer Res 7, 141 (1995). https://doi.org/10.1007/BF03014412
- Alkaline phosphatase isoenzymes
- Gastric cancer
- Light microscopy
- Electron microscopy