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Cardiac output response to altered acid-base status during diethyl ether anaesthesia


The effects of acid-base changes on cardiac output during diethyl ether anaesthesia were studied in 25 mongrel dogs prepared by surgically implanting a plastic encased non-ferrous core electromagnetic probe on the ascending aorta. The findings are:

  1. (1)

    Metabolic acidaemia produced only slight decrease in cardiac output but a more marked fall became evident with decreasing pH.

  2. (2)

    Respiratory acidaemia led to a slight rise in cardiac output.

  3. (3)

    Respiratory alkalaemia decreased cardiac output.

  4. (4)

    Metabolic alkalaemia also produced a decline in cardiac output.


Les auteurs ont étudié les effets sur le débit cardiaque des modifications de l’équilibre acide-base au cours de l’anesthésie à l’éther chez 25 chiens. On avait préalablement procédé chez ces chiens a une implantation chirurgicale d’une sonde électromagneétique à noyau non-ferreux, placé sur l’aorte ascendante.

Les resultats obtenus ont été:

  1. 1.

    L’acidénie métabolique ne produit qu’une légère diminution du débit cardiaque, mais une baisse plus importante se manifeste avec un pH plus abaissé.

  2. 2.

    L’acidénie respiratoire provoque un légère augmentation du débit cardiaque.

  3. 3.

    L’alcalémie respiratoire abaisse le débit cardiaque.

  4. 4.

    L’alcalémie méabolique produit également une diminution du débit cardiaque.


  1. 1.

    Carson, S.A.A., ChorleY, G.E., Hamilton, F.N., Minzel, J.C, Schlobolhm, R.M., Morris, L.E., &Lee, Do-Chil. Variation in cardiac output with acid-base changes in the anaesthetized dog. J. Appl. Physiol.20: 5, 948–953 (1965).

  2. 2.

    Tomlin, P.J., Schlobohm, R.M., Carson, S.A.A., &Morris, L.E. Variation in cardiac output with acid-base changes in the halothane anaesthetized dog. Abstract: Brit. J. Anaesth.38:660 (1966).

  3. 3.

    Schlobohn, R.M., Hamilton, F.N., Tomlin, P.J., & Morris, L.E. Halothane, peripheral vascular resistance and respiratory acidosis.

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    Sodipo, J.O. Effects of propranolol on cardiovascular response to hypercapnia with halothane anaesthesia. Fed. Proc.29: 476 (1970).

  5. 5.

    Stoyka, W.W., Murphy, P.V., &Morris, L.E. Cardiac output variations with acid-base change during trifluoro-ethyl-vinyl-ether (Fluoromar). Fed. Proc.29: 525 (1970).

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    Stoyka, W.W. Cardiac output changes with altered acid-base status during methoxyflurane anaesthesia. Can. Anaesth. Soc. J.19: 119–128 (1972).

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    EdgeR, E.I., Brandstater, B., Saidman, L.J., Regan, M.J., SeveRinghaus, J.W., &Munson, E.S. Equipotent alveolar concentrations of methoxyflurane, halothane, diethyl-ether, fluroxene, cyclopropane, xenon and nitrous oxide in the dog. Anesthesiology26: 771–777 (1965).

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Author information

Correspondence to Joseph O. Sodipo or Do-Chil Lee or Lucien E. Morris.

Additional information

This work was carried out at the University of Toronto, Anaesthesia Research Laboratory at St. Michael’s Hospital, Toranto.

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Sodipo, J.O., Lee, D. & Morris, L.E. Cardiac output response to altered acid-base status during diethyl ether anaesthesia. Canad. Anaesth. Soc. J. 22, 673–679 (1975).

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  • Cardiac Output
  • Methoxyflurane
  • Fluroxene
  • Diethyl Ether Anaesthesia
  • Electromagnetic Flow Probe