Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Heparin and protamine interaction

Interaction de l’héparine et de la protamine

  • 385 Accesses

  • 5 Citations

References

  1. 1

    Komatsu H, Enzan K, Matsuura S, Kurosawa S, Mitsuhata H. Systemic hypotensive response to protamine caused by chronic inhibition of nitric oxide synthase in rats. Can J Anaesth 1998; 45: 1186–89.

  2. 2

    Loubser PG. Effect of methylprednisolone on complement activation during heparin neutralization. J Cardiovasc Pharmacol 1997; 29: 23–7.

  3. 3

    Kambam J, Meszaros R, Merrill W, Stewart J, Smith BE, Bender H. Prophylactic administration of histamine1 and histamine2 receptor blockers in the prevention of protamine-related haemodynamic effects. Can J Anaesth 1990; 37: 420–2.

  4. 4

    Raikar GV, Hisamochi K, Raikar B-LN, Schaff HV. Nitric oxide inhibition attenuates systemic hypotension produced by protamine. J Thorac Cardiovasc Surg 1996; 111: 1240–6.

  5. 5

    Evora PRB, Pearson PJ, Schaff HV. Protamine induces endothelium-dependent vasodilatation of the pulmonary artery. Ann Thorac Surg 1995; 60: 405–10.

  6. 6

    Morita K, Ihnken K, Buckberg GD, Sherman MP, Ignarro LJ. Pulmonary vasoconstriction due to impaired nitric oxide production after cardiopulmonary bypass. Ann Thorac Surg 1996; 61: 1775–80.

  7. 7

    Belboul A, Al-Khaja N. The effect of protamine on the cpicardial microflow and the graft flow in openheart surgery. Perfusion 1997; 12: 99–106.

  8. 8

    Li J, Hajarizadeh H, La Rosa CA, Rohrer MJ, Vander Salm ThJ, Cutler BS. Heparin and protamine stimulate the production of nitric oxide. J Cardiovasc Surg 1996; 37: 445–52.

  9. 9

    Hill GE, Springall DR, Robbins RA. Aprotinin is associated with a decrease in nitric oxide production during cardiopulmonary bypass. Surgery 1997; 121: 449–55.

  10. 10

    Troncy E, Erancœur M, Salazkin I, et al. Extra-pulmonary effects of inhaled nitric oxide in swine with and without phenylephrine. Br J Anaesth 1997; 79: 631–40.

Download references

Author information

Correspondence to Gilbert Blaise.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Blaise, G. Heparin and protamine interaction. Can J Anaesth 45, 1144 (1998). https://doi.org/10.1007/BF03012453

Download citation

Keywords

  • Nitric Oxide
  • Pulmonary Hypertension
  • Protamine
  • Systemic Hypotension
  • Good Drug Combination