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A simple objective parameter for perfusion study of renal transplant

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We proposed a simple parameter, the kidney-to-aorta ratio (KAR), for evaluation of renal transplant perfusion. KAR was calculated from the peak counts of the kidney and the aorta. The calculated values were compared with the visual interpretation of the radionuclide first-pass flow study, percent renal uptake (%RU), and tubular extraction rate (TER) by Bubeck’s one point sampling method in 37 studies. KAR correlated well with the visual interpretation of the flow study and the other quantitative parameters. Representative cases, which showed the usefulness of KAR for the objective assessment of the perfusion status of renal transplants, were presented. In conclusion, KAR is a simple and practically useful parameter for objective evaluation and follow-up of renal transplant perfusion.

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  1. 1.

    Manier SM, VanNostrand D, Kyle RW. Primer and atlas for renal transplant scintigraphy.Clin Nucl Med 1985; 10: 52–62.

  2. 2.

    Dubovsky EV, Russell CD, Erbas B. Radionuclide evaluation of renal transplants.Semin Nucl Med 1995; 25: 49–59.

  3. 3.

    Hilson AJW, Maisey MN, Brown C, Ogg CS, Bewick MS. Dynamic renal transplant imaging with Tc-99m-DTPA supplemented by a transplant perfusion index in the management of renal transplants.J Nucl Med 1978; 19: 994–1000.

  4. 4.

    Kirchner PT, Goldman MH, Leapman SB, Kiepfer RF. Clinical application of the kidney to aortic blood flow index (K/A Ratio).Contr Nephrol 1978; 11: 120–126.

  5. 5.

    Preston DF, Luke RG. Radionuclide evaluation of renal transplants.J Nucl Med 1979; 20: 1095–1097.

  6. 6.

    Baillet G, Ballarin J, Urdaneta N, Campos H, de Vernejoul P, Fermanian J, et al. Evaluation of allograft perfusion by radionuclide first pass study in renal failure following renal translantation.Eur J Nucl Med 1986; 11: 463–469.

  7. 7.

    Lear JL, Raff U, Jain R, Horgan G. Quantitative measurement of renal perfusion following transplant surgery.J Nucl Med 1988; 29: 1656–1661.

  8. 8.

    Ash J, DeSouza M, Peters M, Wilmot D, Hausen D, Gilday D. Quantitative assessment of blood flow in pediatric recipients of renal transplants.J Nucl Med 1990; 31: 580–585.

  9. 9.

    Nicoletti R. Evaluation of renal transplant perfusion by functional imaging.Eur J Nucl Med 1990; 16: 733–739.

  10. 10.

    Bubeck B. Renal clearance determination with one blood sampling: improved accuracy and universal application by a new calculation principle.Semin Nucl Med 1993; 23: 73–86.

  11. 11.

    Manier SM, Van Nostrand D, Kyle RW. Primer and atlas for renal transplant scintigraphy.Clin Nucl Med 1985; 10: 118–133.

  12. 12.

    Itoh K, Tsukamoto E, Kakizaki H, Nonomura K, Furudate M. Comparative study of renal scintigraphy with Tc-99m-mercaptoacetyltriglycine and I-123-orthoiodohippurate.Nucl Med Commun 1993; 14: 644–652.

  13. 13.

    Taylor A, Corrigan PL, Galt J, Garcia EV, Folks R, Jones M, et al. Measuring technetium-99m-MAG3 clearance with an improved camera-based method.J Nucl Med 1995; 36: 1689–1695.

  14. 14.

    Taylor A, Ziffer JA, Steves A, Eshima D, Delaney VB, Welchel JD. Clinical comparison of Tc-99m-mercapto-acetyltriglycine.Radiology 1989; 170: 721–725.

  15. 15.

    Bubeck B, Brandau W, Weber E, Kalble T, Parekh N, Georgi P. Pharmacokinetics of technetium-99m-MAG3 in humans.J Nucl Med 1990; 31: 1285–1293.

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Correspondence to Kiyoshi Koizumi M.D..

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Koizumi, K., Kakiuchi, H., Sacuchi, T. et al. A simple objective parameter for perfusion study of renal transplant. Ann Nucl Med 15, 27–32 (2001).

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Key words

  • renal transplantation
  • renal perfusion
  • Tc-99m-MAG3
  • renal scintigraphy