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Contrôle de l’acidité gastrique par la cimétidine donnée en prémédication avant l’anesthésie générale: efficacité et tolérance

RéSUMé

La cimétidine administrée à la dose de 400 mg par voie intramusculaire 60 minutes avant le début de l’anesthésie diminue l’acidité gastrique durant toute l’anesthésie générale, sans modifier significativement le volume des sécrétions. Elle diminue le pourcentage des sujets présentant un pH gastrique inférieur à 2,5 à l’induction et au réveil.

La cimétidine ne semble pas modifier le profil d’action des produits couramment utilisés en anesthésie. Elle n’entraîne pas de modifications significatives des principaux paramètres cardiovasculaires et électrocardiographiques.

Abstract

Cimetidine 400 mg was administered intramuscularly 60 minutes before the beginning of general anaesthesia. The double blind experiment was conducted on 84 patients divided in two groups: cimetidine and control. There was no difference in gastric fluid volume between the two groups during general anaesthesia, but acid secretion decreased significantly in the cimetidine group. Values of pH lower than 2.5 were observed in 33.3 percent at induction and 34 per cent at recovery in the control group against 14.6 per cent and 0 per cent in the cimetidine group.

Clinical tolerance to cimetidine was studied in 100 patients during operation. Cimetidine did not alter pharmacological action of usual anaesthetics. There were no significant changes in cardiovascular and electrocardiographic data.

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Author information

Correspondence to D. Riche or Ch. Conseiller or B. Coulbois or D. Ortega or M-Ch. Terestchenko or J-M. Pacouret.

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Tirés à part: Christian Conseiller — même adresse.

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Riche, D., Conseiller, C., Coulbois, B. et al. Contrôle de l’acidité gastrique par la cimétidine donnée en prémédication avant l’anesthésie générale: efficacité et tolérance. Canad. Anaesth. Soc. J. 28, 442–449 (1981). https://doi.org/10.1007/BF03010353

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Mots Clefs

  • Premedication
  • cimétidine
  • Acidite Gastrique
  • contrôle
  • cimétidine