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Preoperative diclofenac sodium reduces postlaparoscopy pain

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Abstract

Post-laparoscopy pain can increase recovery time and delay patient discharge. While previous studies have focused on the problems of nausea and vomiting, the purpose of this study was to assess the effect of diclofenac (a non-steroidal antiinflammatory drug) in the treatment of post-laparoscopy pain. Diclofenac (50 mg) or placebo was administered pr randomly and double-blind, prior to induction of anaesthesia, to 46 women. Pain intensity was assessed by the patient using a visual analogue scale 1, 12 and 24 hr after surgery. Postoperative analgesic requirements and side effects were also studied. Diclofenac resulted in better pain relief at 24 hr (1.0 vs 2.5, P < 0.05) and reduced the number of patients who needed additional postoperative analgesics (7 vs 15, P < 0.05). There was no difference in the incidence of side effects. These data suggest that diclofenac reduces post-laparoscopy pain and postoperative analgesic requirements.

Résumé

La douleur postlaparoscopique ralentit la récupération et retarde le congé. Alors que des études antérieures portaient sur les phénomènes de nausées et de vomissements, l’objectif de cette étude est d’évaluer les effets du diclofénac (un antiinflammatoire non-stéroïdien) sur la douleur postlaparascopie. Le diclofénac 50 mg ou un placébo sont administrés à 46 femmes au hasard et à double insu par la voie rectale avant l’induction de l’anesthésie. L’intensité de la douleur est évaluée par la patiente à l’aide d’une échelle visuelle analogique 1 hre, 12 et 24 hres après la chirurgie. Les besoins analgésiques postopératoires et les effets secondaires sont aussi étudiés. Le diclofénac produit un meilleur soulagement à 24 hres (1,0 vs 2,5, P < 0,05) et diminue le nombre de patientes qui ont besoin d’analgésiques additionnels (7 vs 15, P < 0,05). Il n’y a pas de différence dans l’incidence des effets secondaires. Ces données suggèrent que le diclofénac diminue la douleur postlaparoscopie et les besoins postopératoires d’analgésiques.

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Author information

Correspondence to Lars E. Gillberg.

Additional information

Kristianstad County Council provided financial support. Ciba-Geigy, Sweden, supplied the diclofenac and placebo used in this study.

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Gillberg, L.E., Harsten, A.S. & Ståhl, L.B. Preoperative diclofenac sodium reduces postlaparoscopy pain. Can J Anaesth 40, 406–408 (1993). https://doi.org/10.1007/BF03009507

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Key words

  • analgesics: diclofenac
  • pain: postoperative
  • surgery: laparoscopy