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Factors affecting the rate of disappearance of sevoflurane in Baralyme

Abstract

The effects of temperature, water and Baralyme exhaustion on the rate of disappearance of sevoflurane in Baralyme were studied in an in vitro model. We found that the rate of disappearance of sevoflurane in Baralyme increased as the temperature increased and decreased as the concentration of water increased. The disappearance of sevoflurane also decreased in the presence of exhausted Baralyme compared with fresh Baralyme. The slower rate of disappearance of sevoflurane in Baralyme in the presence of water and Baralyme exhaustion suggests that the disappearance of sevoflurane may be selflimiting in the clinical setting.

Résumé

Les effets de la température de l’eau et de l’épuisement de l’absorbeur sur le taux de disparition du sévoflurane dans le Baralyme ont été étudiés sur un modèle in vitro. Nous avons trouvé que la vitesse de disparition du sévoflurane dans le Baralyme augmentait avec la température et diminuait en proportion inverse de la concentration hydrique. En présence de Baralyme épuisé, la disparition du sévoflurane diminuait comparativement au Baralyme frais. Le fait que la vitesse de disparition du sévoflurane soit plus lente en présence d’eau et de Baralyme épuisé suggère que la disparition du sévoflurane pourrait se limiter d’elle-même dans un contexte clinique.

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Author information

Correspondence to David T. Wong.

Additional information

Supported, in part, with a grant from Maruishi Pharmaceutical Inc., Osaka, Japan.

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Wong, D.T., Lerman, J. Factors affecting the rate of disappearance of sevoflurane in Baralyme. Can J Anaesth 39, 366 (1992). https://doi.org/10.1007/BF03009047

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Key words

  • anaesthetics, volatile: isoflurane, sevoflurane
  • carbon dioxide: absorption, soda lime, Baralyme
  • equipment: absorbers
  • measurement techniques: chromatography, gas