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Lack of tolerance to cyclopropane and cross-tolerance to halothane in rats

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Cyclopropane requirement (MAC) in rats was determined before, during, and after repeated exposure to anaesthetic concentrations of cyclopropane and halothane for one hour every day for 20 and 30 days, respectively. MAC values during and after exposure ranged from 93 to 103 per cent (mean = 99 per cent) of control values, which indicates a lack of significant tolerance to cyclopropane or a cross-tolerance between cyclopropane and halothane.


On a déterminé les besoins en cyclopropane (MAC) dans deux groupes de rats avant, pendant et après des administrations répétées de concentrations anesthésiques de cyclopropane et d’halolhane durant une heure chaque jour, pendant 20 et 30 jours respectivement. Les valeurs du MAC pendant et après ces administrations ont varié entre 93 et 103% (moyenne: 99%) des valeurs contrôles, ce qui indique que ces administrations répétées n’ont pas déclenché de tolérance au cyclopropane ou de tolérance croisée à l’égard de l’halothane.


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Correspondence to Edwin S. Munson.

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Munson, E.S. Lack of tolerance to cyclopropane and cross-tolerance to halothane in rats. Can Anaesth Soc J 31, 642–645 (1984). https://doi.org/10.1007/BF03008760

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Key words

  • anaesthetics, gases: cyclopropane, halothane
  • interactions: cross-tolerance, tolerance
  • pharmacokinetics
  • tolerance
  • potency, anaesthetic: minimum alveolar concentration