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Lack of tolerance to cyclopropane and cross-tolerance to halothane in rats

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Abstract

Cyclopropane requirement (MAC) in rats was determined before, during, and after repeated exposure to anaesthetic concentrations of cyclopropane and halothane for one hour every day for 20 and 30 days, respectively. MAC values during and after exposure ranged from 93 to 103 per cent (mean = 99 per cent) of control values, which indicates a lack of significant tolerance to cyclopropane or a cross-tolerance between cyclopropane and halothane.

Résumé

On a déterminé les besoins en cyclopropane (MAC) dans deux groupes de rats avant, pendant et après des administrations répétées de concentrations anesthésiques de cyclopropane et d’halolhane durant une heure chaque jour, pendant 20 et 30 jours respectivement. Les valeurs du MAC pendant et après ces administrations ont varié entre 93 et 103% (moyenne: 99%) des valeurs contrôles, ce qui indique que ces administrations répétées n’ont pas déclenché de tolérance au cyclopropane ou de tolérance croisée à l’égard de l’halothane.

References

  1. 1

    Johnstone RE, Kulp RA, Smith TC. Effects of acute and chronic ethanol administration on isoflurane requirement in mice. Anesth Analg 1975; 54:277–81.

  2. 2

    Chalon J, Tang C-K, Roberts C et al. Murine auto- and cross-tolerance to volatile anaesthetics. Can Anaesth Soc J 1983; 30:230–4.

  3. 3

    Munson ES, Hoffman, JC, DiFazio CA. The effects of acute hypothyroidism and hyperthyroidism on cyclopropane requirement (MAC) in rats. Anesthesiology 1968; 29:1094–8.

  4. 4

    Munson ES, Martucci RW, Smith RE. Circadian variations in anesthetic requirement and toxicity in rats. Anesthesiology 1970; 32:507–14.

  5. 5

    Eger EI II, Saidman LJ, Brandstater B. Minimum alveolar anesthetic concentration: A standard of potency. Anesthesiology 1965; 26:756–63.

  6. 6

    Smith RA, Winter PM, Smith M, Eger EI 11. Rapidly developing tolerance to acute exposures to anesthetic agents. Anesthesiology 1979; 50:496–500.

  7. 7

    Smith RA, Winter PM, Smith M, Eger EI 11. Tolerance to and dependence on inhalational anesthetics. Anesthesiology 1979; 50:505–9.

  8. 8

    Smith RA, Winter PM, Smith M, Eger EI II. Convulsions in mice after anesthesia. Anesthesiology 1979; 50:501–4.

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Author information

Correspondence to Edwin S. Munson.

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Munson, E.S. Lack of tolerance to cyclopropane and cross-tolerance to halothane in rats. Can Anaesth Soc J 31, 642–645 (1984). https://doi.org/10.1007/BF03008760

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Key words

  • anaesthetics, gases: cyclopropane, halothane
  • interactions: cross-tolerance, tolerance
  • pharmacokinetics
  • tolerance
  • potency, anaesthetic: minimum alveolar concentration
  • TOLERANCE