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Douleurs neuropathiques chez l’enfant

2. Propositions thérapeutiques

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Les douleurs neuropathiques sont difficiles à traiter chez l’adulte, et ce d’autant qu’elles ont des composantes variées en tonalité et en intensité. Celles du jeune enfant poseront beaucoup plus de problème car s’il existe un consensus pour l’adulte et pour l’enfant sur trois types de médicaments, antiépileptiques, antidépresseurs et topiques locaux, la palette est encore trop restreinte pour obtenir des résultats thérapeutiques aussi bon que dans les douleurs nociceptives.


Neuropathic pain is difficult to treat in adults due to the variety of intensity and quality of the pain. In children the difficulty increases because while there is a consensus on the use of three types of medication, anticonvulsants, antidepressants and topical local medications, the tools are still too limited to provide analgesia as efficiently as for nociceptive pain.

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  1. 1.

    Backonja M., Arndt G. Gombar K.A. et al.: Response of chronic neuropathic pain syndromes to ketamine: a preliminary study.Pain 56, 51–57, 1994.

  2. 2.

    Bernstein A.L.: Vitamin B6 in clinical neurology.Ann. NY Acad Sci. 585, 250–260, 1990.

  3. 3.

    Blackburn Munro G. andFleetwood Walker S.M.: The effects of Na+ channel blockers on somatosensory processing by rat dorsal horn neurones.Neurosciences & Behavior 8, 1549–1554, 1997.

  4. 4.

    Calvino B.: Kétamine et système NMDA.In: SOFRED, 7e Congrès Annuel; mise au point. Paris, 23–30, 1997.

  5. 5.

    Collins J.J., Kerner J., Sentivany S. andBerde C.B.: Intravenous amitriptyline in pediatrics.J. Pain Symptom. Manag. 10 (6), 471–475, 1995.

  6. 6.

    Collins J.J., Grier H.E., Sethna N.F. et al.: Regional anesthesia for pain associated with terminal pediatric malignancy.Pain 65 (1), 63–69, 1996.

  7. 7.

    Eschalier A., Fialip J., Varoquaux O. et al.: Patterns of administration of antidepressants in animals. 1) Implication of antinociceptive action of clomipramine in mice.J. Pharmacol. Exp. Ther. 245, 963–968, 1988.

  8. 8.

    Guieu R., Paragut J.C., Roussel P. et al.: Adenosine and neuropathic pain.Pain 68, 271–274, 1996.

  9. 9.

    Hansson P.: Neurogenic pain: diagnosis and treatment.Pain Clinical Updates II (3), 1–4, 1994.

  10. 10.

    Lipton S.A.: HIV-related neuronal injury. Potential therapeutic intervention with calcium channel antagonists and NMDA antagonists.Mol. Neurobio. 18, 181–196, 1994.

  11. 11.

    Lipton S.A. andStamler J.S.: Actions of redox-related congeners of nitric oxide at the NMDA receptor.Neuropharmacol. 33 (11), 1229–1233, 1994.

  12. 12.

    Mc Quay H, Carroll D., Jadad A.R. et al.: Anticonvulsant drugs for management of pain: a systematic review.BMJ 311, 1047–1052, 1995.

  13. 13.

    Marchettini P., Lacerenza M., Marangoni C. et al.: Lidocaine test in neuralgia.Pain 48 (3), 377–382, 1992.

  14. 14.

    Pedespan J.M., Fontand D. andGuillard J.M.: Utilisation de la lamotrigine chez l’enfant.In: G. Pons, O. Dulac et Y. Benari. Les médicaments antiépileptiques chez l’enfant. Ed. Springer Verlag, Paris, 201–206, 1994.

  15. 15.

    Persson J., Axelsson G., Hallin R.G. andGustafsson L.L.: Beneficial effects of ketamine in a chronic pain state with allodynia possibly due to central sensitization.Pain 60 (2), 217–222, 1995.

  16. 16.

    Roach E.S., Delgado M., Anderson L. et al.: Carbamazepine trial for Lesch-Nyhan self-mutilisation.J. Child. Neurol. 11 (6), 476–478, 1996.

  17. 17.

    Stanfa L.C., Singh L., Williams R.G. andDickenson A.H.: Gabapentin, ineffective in normal rats, markedly reduces C-fibre evoked responses after inflammation.Neurosci. Biobehav. Rev. 8 (3), 587–590, 1997.

  18. 18.

    Stannard C.F. andPorter G.E.: Ketamine hydrochloride in the treatment of phantom limb pain.Pain 54, 227–230, 1993.

  19. 19.

    Vargas-Schaffer G. andPichard-Léandri E.: La douleur neuropathique chez le jeune enfant cancéreux.Eur. J. Palliative Care 3 (3), 95–98, 1996.

  20. 20.

    Wiesenfeld-Hallin Z., Hao J.X. andXu X.J.: Mecanisms of central pain. Proceedings of the 8th World Congress of Pain. Progress in Pain Research & Management. ASP Press, Seattle, 575, 589, 1997.

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Correspondence to E. Pichard-Léandri.

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Pichard-Léandri, E. Douleurs neuropathiques chez l’enfant. Doul. et Analg. 13, 11 (2000). https://doi.org/10.1007/BF03008085

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Key words

  • Antidepressant
  • anticonvulsant
  • topical medications
  • NMDA antagonist
  • Na Blocker Channel
  • Ca Blocker Channel